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However, selective detection of MPO activity remains challenging because most HOCl\u2010responsive fluorescent probes operate through nonspecific oxidative mechanisms, rendering them vulnerable to interference from competing reactive oxygen and nitrogen species. Here, we present an MPO\u2010reporting fluorescent platform based on a\n                    <jats:italic>meso<\/jats:italic>\n                    \u2010carboxamide\u2010substituted 3,5\u2010dimethyl BODIPY scaffold that exploits the electrophilic chlorinating reactivity of MPO\u2010derived HOCl. The lead probe undergoes rapid chlorination at the 2,6\u2010positions, generating highly emissive products with ca. 40 nm bathochromic shifts and overcoming the minimal spectral responses and fluorescence quenching that have limited earlier chlorination\u2010based designs. The modular\n                    <jats:italic>meso<\/jats:italic>\n                    \u2010carboxamide architecture further allows facile incorporation of targeting motifs without compromising probe performance. This platform enables quantitative MPO assays, cellular imaging of exogenous and endogenous MPO\u2010derived HOCl, discrimination between cancer and normal cells based on redox differences, and noninvasive visualization of MPO\u2010driven inflammation in a mouse model of atopic dermatitis. These results establish electrophilic chlorination as a viable design strategy for selective MPO\u2010responsive fluorescent probes and provide a versatile tool for investigating MPO\u2010associated inflammatory pathophysiology in biological and preclinical disease models.\n                  <\/jats:p>","DOI":"10.1002\/anie.9709775","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:06:01Z","timestamp":1789571161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chlorination\u2010Driven BODIPY Fluorescent Probes for the Selective Monitoring of Myeloperoxidase Activity in Cells and Inflamed Mouse Models"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4818-6639","authenticated-orcid":false,"given":"Siyoung","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-8977","authenticated-orcid":false,"given":"Yongyang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Life Science Chung\u2010Ang University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-1378","authenticated-orcid":false,"given":"Jeehyeon","family":"Bae","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chung\u2010Ang University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngmi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University  Seoul South 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