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In contrast to the established organic PTAs with donor\u2013acceptor architectures, herein, we developed a new class of atomically precise BN\u2010doped polycyclic hydrocarbons (PHs) featuring stable diradicaloid (\n                    <jats:bold>BN\u2010Dira<\/jats:bold>\n                    :\n                    <jats:italic>y<\/jats:italic>\n                    <jats:sub>0<\/jats:sub>\n                    \u00a0=\u00a00.74) and tetraradicaloid (\n                    <jats:bold>BN\u2010Tetra<\/jats:bold>\n                    :\n                    <jats:italic>y<\/jats:italic>\n                    <jats:sub>0<\/jats:sub>\n                    \u00a0=\u00a00.43,\n                    <jats:italic>y<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u00a0=\u00a00.30) character for high\u2010efficiency photothermal therapy (PTT). Our design is based on the synergistic integration of 1,2\u2010BN units and radical engineering within an expanded \u03c0\u2010conjugated skeleton. The complementary electron\u2010donating (N) and electron\u2010accepting (B) sites effectively modulate the intramolecular charge distribution, which promotes effective electron delocalization. The resulting compounds exhibit exceptional ambient stability, with the tetraradicaloid species demonstrating half\u2010lives of over 1\u00a0year. In addition, the engineered compound\n                    <jats:bold>BN\u2010Dira<\/jats:bold>\n                    exhibit high NIR absorption and PCE of 83.6%. In vitro, they induce rapid cancer cell apoptosis under NIR irradiation (808\u00a0nm). In vivo murine models confirm efficient tumor eradication with minimal side effects. This work establishes a new protocol for stable, radical\u2010based PH PTAs, providing a solution for high\u2010performance cancer therapies that can be translated into clinical applications.\n                  <\/jats:p>","DOI":"10.1002\/anie.9715423","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:02:54Z","timestamp":1783789374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Engineering BN\u2010Doped Open\u2010Shell Polycyclic Hydrocarbons for Enhanced Photothermal Conversion and Therapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Peiyun","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Chemistry The University of Hong Kong  Hong Kong China"},{"name":"Chemistry and Chemical Engineering Guangdong Laboratory  Shantou 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