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VDR activation has complex and cell\u2010specific effects in multiple tissues and spatial control of VDR activity is desirable. Here, we developed vitD mimetics bearing a photo\u2010switchable azobenzene motif to achieve spatiotemporal resolution in VDR activation. Structure\u2010guided tuning of regiochemistry and H\u2010bonding motifs provided a potent and selective vitD mimetic that can be reversibly switched in cellulo between agonist and antagonist states with light. In a model of osteogenesis, this unique bidirectional precision tool mediated light\u2010dependent osteogenic and osteolytic effects.<\/jats:p>","DOI":"10.1002\/anie.9726457","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:45:43Z","timestamp":1778503543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Agonist\/Antagonist Photo\u2010Switchable Vitamin D Mimetic Enables Bidirectional Optical Control of VDR"],"prefix":"10.1002","volume":"65","author":[{"given":"Xiu","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Pharmacy Ludwig\u2010Maximilians\u2010University (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-3394","authenticated-orcid":false,"given":"Sabine","family":"Willems","sequence":"additional","affiliation":[{"name":"Department of Pharmacy 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