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Here we report a dinuclear (salen)titanium\u2010catalyzed radical ring\u2010opening strategy for the kinetic resolution of 2\u2010aryl oxetanes under mild conditions. The reaction accommodates diverse aryl\u2010, heteroaryl\u2010, and drug\u2010conjugated substrates, delivering enantioenriched oxetanes with high regio\u2010 and enantioselectivity. The resulting oxetanes serve as versatile chiral platforms and enable concise, modular, and enantio\u2010retentive access to pharmaceutically relevant targets, including (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010Atomoxetine, (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010Nisoxetine, and (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010Fluoxetine. Mechanistic studies reveal distinct stability\/reactivity relationships between diastereomeric Ti\u2013oxetane intermediates, differentiated by an unusual ligand\u2013substrate C\u2013H\u00b7\u00b7\u00b7\u03c0 interaction, display distinct stability\/reactivity relationships during C\u2500O bond homolysis. Beyond establishing a broadly useful kinetic resolution of 2\u2010aryl oxetanes, this work reveals an unusual mode of attractive ligand\u2013substrate recognition in salen\u2013titanium radical catalysis.\n                  <\/jats:p>","DOI":"10.1002\/anie.9795533","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:11:31Z","timestamp":1786954291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetric Kinetic Resolution of 2\u2010Aryl Oxetanes by Dinuclear Titanium Radical Catalysis"],"prefix":"10.1002","volume":"65","author":[{"given":"Huaxi","family":"Sun","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University  Jinan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingda","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University  Jinan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Mei","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University  Jinan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-6569","authenticated-orcid":false,"given":"Jie","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University  Jinan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3967-4921","authenticated-orcid":false,"given":"Li\u2010Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University  Jinan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-5419","authenticated-orcid":false,"given":"Yong\u2010Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University  Jinan P. R. China"},{"name":"State Key Laboratory of Microbial Technology Shandong University  Qingdao P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200907155"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200602343"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9018788"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115802"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00274"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1OB00988E"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.21.101"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200805473"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c02975"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c02483"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja809176m"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201300188"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol5005565"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201509888"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201711648"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c03991"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c01133"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01084a034"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202411326"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c00312"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056463\u2010z"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03346"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03408"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja973895x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00194a073"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521\u20103773(19980202)37:1\/2<101::AID\u2010ANIE101>3.0.CO;2\u2010W"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2008.08.107"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b06723"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b13710"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw3913"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c08083"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010020\u201000561\u20106"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5c00121"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja8099757"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja010982n"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/b701431g"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja408027p"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201900557"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00074"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202507673"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2018.05.069"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893\u2010133X(02)00346\u20109"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.1976.tb00595.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1821"},{"key":"e_1_2_8_47_1","unstructured":"The calculations were performed at the SMD(toluene)\/M06\/6\u2010311++G(d p)\/SDD(Ti)\/\/B3LYP\u2010D3BJ\/6\u201031G(d p)\/LANL2DZ(Ti) level of theory. For details see the Supporting Information."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9795533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.9795533","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9795533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:46:57Z","timestamp":1791226017000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.9795533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":46,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,10,5]]}},"alternative-id":["10.1002\/anie.9795533"],"URL":"https:\/\/doi.org\/10.1002\/anie.9795533","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2026-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9795533"}}