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We developed a copper metal\u2010organic framework\u2010based nanoplatform (CuF) with H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    responsiveness and Raman self\u2010tracking capability for cuproptosis\u2010mediated antitumor therapy. CuF was prepared by coordinating Cu\n                    <jats:sup>2+<\/jats:sup>\n                    with an alkyne\u2010bearing ligand, followed by PEGylation and incorporation of an iron\u2010based catalyst. CuF undergoes catalyst\u2010mediated oxidative cleavage of alkynyl bonds under tumor\u2010associated elevated H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    levels, causing CuF degradation and Cu\n                    <jats:sup>2+<\/jats:sup>\n                    release. Released Cu\n                    <jats:sup>2+<\/jats:sup>\n                    causes copper overload in tumor cells, thereby inducing potent cuproptosis. Meanwhile, the resultant aldehydes and acids generated by the oxidative cleavage of alkynes can further synergistically potentiate cuproptosis. Consequently, CuF demonstrated high antitumor efficacy in a 4T1 tumor\u2010bearing mouse model (with a tumor inhibition rate of 91%). Moreover, alkynes in the metal\u2010organic framework (MOF) backbone provided an intrinsically enhanced Raman signal, enabling label\u2010free self\u2010tracking of CuF distribution and degradation in cells and tissue sections through Raman imaging. Overall, this work not only provides a new paradigm for cuproptosis\u2010based anticancer agents, but also offers a versatile strategy for engineering H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    responsive materials and Raman imaging nanoplatforms.\n                  <\/jats:p>","DOI":"10.1002\/anie.9809366","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:19:41Z","timestamp":1791109181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Raman Self\u2010Tracking Copper Metal\u2010Organic Framework\u2010Based Nanoplatform for Cuproptosis Cancer Therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1316-8156","authenticated-orcid":false,"given":"Yujie","family":"Duan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xidong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-5807","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010022\u201002485\u20100"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.150524"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121335"},{"key":"e_1_2_8_6_1","first-page":"1001","article-title":"The Cell Death Pathway Induced by Metal Halide Complexes of Pyridine and Derivative Ligands in Hepatocellular Carcinoma Cells\u2013Necrosis or Apoptosis?","volume":"16","author":"Kismali G.","year":"2012","journal-title":"European Review for Medical & Pharmacological Sciences"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202504554"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010024\u201000876\u20100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202309388","article-title":"Stimulus\u2010Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy","volume":"11","author":"Hu F.","year":"2024","journal-title":"Advanced Science"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c12796"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212267"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202504121"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308241"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c04022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c13225"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202522613"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1126\/science.283.5405.1148","article-title":"A Chemically Functionalizable Nanoporous Material [Cu3(TMA)2 (H2O)3]n","volume":"283","author":"Chui S. 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