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We herein report that a methyl naphthyl (MeNAP) palladium trifluoroacetate\/\n                    <jats:italic>\n                      <jats:sup>t<\/jats:sup>\n                    <\/jats:italic>\n                    BuBrettPhos catalyst with lithium bis(trimethylsilyl)amide (LiHMDS) as the base enables \u03b1\u2010arylations of in situ generated enolates with non\u2010activated aryl fluorides. The reaction proceeds under mild conditions at room temperature and extends to ketone, ester, nitrile, and even amide enolates. DFT calculations reveal that the coordination of lithium salts to the fluorine atom decisively facilitates the insertion of Pd into the C\u2500F bond, explaining why this so far elusive reaction is now possible at such exceptionally mild conditions.\n                  <\/jats:p>","DOI":"10.1002\/anie.9818208","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T18:08:22Z","timestamp":1785089302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catalytic C\u2013F Bond Activation at Room Temperature: Enolate Cross\u2010Couplings Enabled by [Pd(1\u2010MeNAP)TFA]\n                    <sub>2<\/sub>\n                    and LiHMDS"],"prefix":"10.1002","volume":"65","author":[{"given":"Nele","family":"Kr\u00fcger","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry I Fakult\u00e4t f\u00fcr Chemie und Biochemie Ruhr\u2010Universit\u00e4t Bochum  Bochum 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