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However, conventional synthetic routes via hydrogen isotope exchange (HIE) usually require expensive isotopic sources (D\n                    <jats:sub>2<\/jats:sub>\n                    , DMSO\u2010\n                    <jats:italic>d<\/jats:italic>\n                    <jats:sub>6<\/jats:sub>\n                    , acetone\u2010\n                    <jats:italic>d<\/jats:italic>\n                    <jats:sub>6<\/jats:sub>\n                    ), metal complex catalysts, or hazardous operations (e.g., \u2265120\u2009\u00b0C and 10\u2009bar H\n                    <jats:sub>2<\/jats:sub>\n                    ). Here, we report a visible\u2010light\u2010induced deuteration strategy for benzylic C(\n                    <jats:italic>sp<\/jats:italic>\n                    <jats:sup>3<\/jats:sup>\n                    )\u2013H bonds using a Pd\/C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    photocatalyst in D\n                    <jats:sub>2<\/jats:sub>\n                    O under 410\u00a0nm irradiation and 1\u00a0bar Ar at room temperature. The protocol enabled the late\u2010stage benzylic deuteration of 54 alkyl(hetero)arenes (containing diverse electron\u2010withdrawing or electron\u2010donating groups) with excellent deuteration incorporation up to 99%, including highly functionalized natural products and pharmaceuticals. The successful gram\u2010scale synthesis of a CD\n                    <jats:sub>3<\/jats:sub>\n                    \u2010containing drug (2.17\u00a0g, 10\u00a0mmol) also demonstrated the scalability and sustainability of our photo\u2010induced approach. Mechanism studies revealed that active D species (Pd\u2013D\n                    <jats:sup>\u03b4\u2212<\/jats:sup>\n                    and N\u2013D\n                    <jats:sup>\u03b4+<\/jats:sup>\n                    ) from heterolytic dissociation at the interface between Pd nanoparticles and the C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    support could initiate deuteration of benzylic C(\n                    <jats:italic>sp<\/jats:italic>\n                    <jats:sup>3<\/jats:sup>\n                    )\u2013H bonds in D\n                    <jats:sub>2<\/jats:sub>\n                    O.\n                  <\/jats:p>","DOI":"10.1002\/anie.9855820","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:26:31Z","timestamp":1790231191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Visible\u2010Light\u2010Induced Deuteration of Benzylic C(\n                    <i>sp<\/i>\n                    <sup>3<\/sup>\n                    )\u2500H Bonds in D\n                    <sub>2<\/sub>\n                    O via Heterolytic Dissociation Mode"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5377-5487","authenticated-orcid":false,"given":"Jie","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioinspired Interfacial Materials Science School of Nano Science and Technology School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui 230026 China"},{"name":"Suzhou Institute for Advanced Research University of Science and Technology of China  Suzhou Jiangsu 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioinspired Interfacial Materials Science School of Nano Science and Technology School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui 230026 China"},{"name":"Suzhou Institute for Advanced Research University of Science and Technology of China  Suzhou Jiangsu 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingrui","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering (iBHE) Tsinghua Shenzhen International Graduate School, Tsinghua University  Shenzhen Guangdong 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-8491","authenticated-orcid":false,"given":"Yi\u2010Tao","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioinspired Interfacial Materials Science School of Nano Science and Technology School of Chemistry and Materials Science University of Science and Technology of China  Hefei Anhui 230026 China"},{"name":"Suzhou Institute for Advanced Research University of Science and Technology of China  Suzhou Jiangsu 215123 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