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Although the reaction products, which incorporate acyclic tetrasubstituted alkenes, are challenging substrates for asymmetric hydrogenation, trifluoroethanol (TFE) enabled rhodium\u2010Walphos\u2010catalyzed hydrogenation occurs with high levels of enantioselectivity. Thus, through successive transfer hydrogenative coupling\u2010asymmetric hydrogenation events, abundant nitrile and acrylate feedstocks are converted to enantioenriched \u03b2\u2010amino esters. This method represents a new catalytic transformation of nitriles and the first reductive C\u2500C coupling of nitriles beyond the use of stoichiometric metals or metalloids.\n                  <\/jats:p>","DOI":"10.1002\/anie.9880459","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T09:30:56Z","timestamp":1787391056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ruthenium\u2010Catalyzed Nitrile\u2010Acrylate Reductive Coupling by 2\u2010Propanol: Synthesis of Enantioenriched \u03b2\u2010Amino Esters"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2058-4142","authenticated-orcid":false,"given":"Sebastian","family":"H\u00f6thker","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2237-717X","authenticated-orcid":false,"given":"Colin E.","family":"Hayter","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6345-3371","authenticated-orcid":false,"given":"Weijia","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-9709","authenticated-orcid":false,"given":"Michael J.","family":"Krische","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5133"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00213"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00053"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202101890"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c02444"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9088296"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC46894A"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201500102"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b09223"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c03859"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja030603l"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4029"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c08732"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c09730"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC01803A"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101648\u20107154"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202764"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.5c00188"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/jr9400001239"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19681010920"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo01273a009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1139\/v78\u2010422"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo061895m"},{"key":"e_1_2_8_25_1","first-page":"95","article-title":"Formation of C\u2010C Bonds via Catalytic Hydrogenation and Transfer Hydrogenation: Vinylation, Allylation and Enolate Addition","volume":"41","author":"Patman R. 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