{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:49:48Z","timestamp":1791888588566,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acrylamides are the dominant electrophilic warheads used in bioactive covalent inhibitors. A limitation of acrylamides and related unsaturated sulfonamides is the narrow scope to modulate their electrophilicity, and hence reactivity, through simple structural modification. Here, we show that vinyl sulfondiimidamides are effective electrophilic motifs for reaction with both sulfur\u2010 and nitrogen\u2010based biologically relevant nucleophiles. We demonstrate that the electrophilicity of these new reagents can be tuned through variation of the imidic N\u2010substituents. Vinyl sulfondiimidamides are prepared via a short sequence that features a Cope elimination as the key alkene\u2010forming step. A broad range of N\u2010substituents can be installed.<\/jats:p>","DOI":"10.1002\/anie.9885717","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:36:13Z","timestamp":1774686973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Functionalization, and Reactivity of Vinyl Sulfondiimidamides"],"prefix":"10.1002","volume":"65","author":[{"given":"Katherine G.","family":"Rodden","sequence":"first","affiliation":[{"name":"Department of Chemistry Chemistry Research Laboratory University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agamemnon E.","family":"Crumpton","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chemistry Research Laboratory University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel E.","family":"Dalton","sequence":"additional","affiliation":[{"name":"Discovery Chemistry, MSD (UK) Limited  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Clegg","sequence":"additional","affiliation":[{"name":"Discovery Chemistry, MSD (UK) Limited  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0636-6471","authenticated-orcid":false,"given":"Michael C.","family":"Willis","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chemistry Research Laboratory University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103799"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01153"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010022\u201000542\u2010z"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00677"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae365"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2024.117902"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa876"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae946"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24451"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7OB01866E"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00749"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01018"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501412a"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5SC02420J"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01907"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2022.02.013"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c04404"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202409240"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c03550"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC00500G"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202524073"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01180a014"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja060595j"},{"key":"e_1_2_5_25_1","unstructured":"\"The Structure of Several Vinyl Sulfondiimidamides Was Confirmed by X\u2010Ray Crystallography. Deposition Number CCDC 2522888 (for6m) 2522889 (for6o) and 2522890 (for8d) Contains the Supplementary Crystallographic Data for this Paper \" these data Are Provided Free of Charge by the Joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9885717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.9885717","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9885717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:22:56Z","timestamp":1791886976000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.9885717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":24,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,5,4]]}},"alternative-id":["10.1002\/anie.9885717"],"URL":"https:\/\/doi.org\/10.1002\/anie.9885717","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,28]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9885717"}}