{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:57:19Z","timestamp":1791226639029,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Inorganic photochemotherapy enables precise spatial and temporal control over anticancer drug activation, offering a promising strategy to reduce systemic toxicity. Two iridium(III) complexes of general formula [Ir(L)(ppy)(terpy)]PF\n                    <jats:sub>6<\/jats:sub>\n                    with L =\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010\n                    <jats:sc>L<\/jats:sc>\n                    \u2010cysteinato methyl ester (cys) or\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010\n                    <jats:sc>L<\/jats:sc>\n                    \u2010selenocysteinato methyl ester (sec), were developed as light\u2010activatable prodrugs with sulfur\u2010 and selenium\u2010based \u201ccaging\u201d groups. Both complexes are stable in the dark but undergo light induced bond cleavage upon visible light activation, following distinct photochemical pathways dictated by the coordinated chalcogen. For the cys complex, an initial oxygen\u2010dependent formation of a sulfinato intermediate is followed by Ir\u2500S bond cleavage. In contrast, the selenium complex first releases dehydroalanine due to Se\u2500C bond cleavage, forming an unprecedented selenite intermediate [Ir(SeO\n                    <jats:sub>3<\/jats:sub>\n                    )(ppy)(terpy)], which was characterized by single crystal x\u2010ray diffraction. The photoactivation leads to high singlet oxygen production quantum yields (40%\u201348%), consistent with a type II photodynamic therapy (PDT) mechanism. Both complexes exhibit minimal dark toxicity (EC\n                    <jats:sub>50\u00a0<\/jats:sub>\n                    &gt;\u00a0150\u00a0\u00b5M) but potent photocytotoxicity in A549 cells under blue and green light photoactivation (460 and 520\u00a0nm). This new class of photocaged iridium(III) pro\u2010sensitizer shows promise for combined PACT\/PDT applications and demonstrates how chalcogen coordination modulates the photoreactivity and therapeutic efficacy of metal complexes.\n                  <\/jats:p>","DOI":"10.1002\/anie.9954997","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:34:37Z","timestamp":1786552477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncaging Iridium(III) Complexes for Combined Photodynamic and Photoactivated Chemotherapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Victoria V. 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