{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:51:37Z","timestamp":1781697097468,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,5,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The Correspondence by Gharib et\u00a0al. challenges our 2012 study on CQD\u2010based Cu\n                    <jats:sup>2+<\/jats:sup>\n                    sensors but introduces no new experimental data. Their failure to reproduce our results stems directly from fundamental errors in materials synthesis. Specifically, they failed to properly synthesize either key material. Regarding AE\u2010TPEA, the core innovation of our work, they deviated from our published protocol, failed to synthesize and validate the identity and purity of the product, and did not report the deviation from the protocol in the Correspondence. Without authentic AE\u2010TPEA, the subsequent experiments are scientifically meaningless. Regarding CQDs, we followed the established method of Li et\u00a0al., a protocol independently reproduced by numerous laboratories worldwide. The authors failed to synthesize the proper fluorescent CQDs because they did not strictly follow the experimental conditions, not because of a flaw in our approach. Furthermore, their own data are internally inconsistent. Three parallel syntheses yielded conflicting results across UV\u2010vis, fluorescence, FTIR, TEM, DLS, and zeta potential measurements, exposing a lack of experimental control. Finally, our work has been widely validated. Over a decade of independent applications, many research groups have confirmed the reproducibility and utility of our approach.\n                  <\/jats:p>","DOI":"10.1002\/anie.9981178","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:15:53Z","timestamp":1775445353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reply to the Correspondence on \u201cCarbon\u2010Dot\u2010Based Dual\u2010Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for in Vivo Imaging of Cellular Copper Ions\u201d"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-7629","authenticated-orcid":false,"given":"Anwei","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-0349","authenticated-orcid":false,"given":"Yang","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906154"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt30985h"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra23410j"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5AN02231B"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2025.115382"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","unstructured":"E.Linnane C.Menard\u2010Moyon andY.Yamada \u201cUnsuccessful Replication of Cellular Copper Ion Imaging Using Carbon Dots \u201d in Peer Community in Registered Reports 2025 101070 Author's Reply on 02 Sep 2025 https:\/\/doi.org\/10.24072\/pci.rr.101070.","DOI":"10.24072\/pci.rr.101070"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-76501-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201109089"},{"key":"e_1_2_6_10_1","unstructured":"M.Gharib M.Said andR.L\u00e9vy \u201cPubPeer Comment on Carbon\u2010Dot\u2010Based Dual\u2010Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for in Vivo Imaging of Cellular Copper Ions \u201dPubPeer(February 2026):2025 https:\/\/pubpeer.com\/publications\/7C749EA281BD18BED4F3672FE6A126#4 accessed."},{"key":"e_1_2_6_11_1","unstructured":"M.Gharib M.Said S.Zrig andR.Levy \u201cN'\u2010[2\u2010[bis(pyridin\u20102\u2010ylmethyl)amino]ethyl]\u2010N'\u2010(pyridin\u20102\u2010ylmethyl)ethane\u20101 2\u2010diamine \u201d Chemotion\u2010Repository https:\/\/www.chemotion\u2010repository.net\/home\/publications\/molecules\/12284."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.31219\/osf.io\/kf9qe"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.31219\/osf.io\/2x3hv_v3"},{"key":"e_1_2_6_14_1","article-title":"Correspondence on \u2033Carbon\u2010Dot\u2010Based Dual\u2010Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for in Vivo Imaging of Cellular Copper Ions","author":"Gharib M.","year":"2026","journal-title":"Angewandte Chemie International Edition"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac501499y"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202410786"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00008"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2017.02.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac404236y"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2017.05.035"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9981178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.9981178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.9981178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:53:01Z","timestamp":1781693581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.9981178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,5]]},"references-count":19,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,5,11]]}},"alternative-id":["10.1002\/anie.9981178"],"URL":"https:\/\/doi.org\/10.1002\/anie.9981178","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,5]]},"assertion":[{"value":"2026-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9981178"}}