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Herein, we proposed an anthraquinone (AQ)\u2010based single\u2010component \u201celectron reservoir\u2010pump\u201d strategy to enhance the electron transfer ability of type I photosensitizers. In this molecular design, the AQ scaffold functioned as an intrinsic electron reservoir, while the electron\u2010rich tetraphenylethylene (TPE) served as an electron pump that actively donated electrons. The synergistic reservoir\u2010pump interaction enabled the photosensitizer AQTPE to undergo photo\u2010disproportionation and generate radical ion pairs: the anionic radical efficiently reduced O\n                    <jats:sub>2<\/jats:sub>\n                    to form superoxide (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212\u2022<\/jats:sup>\n                    ), while the cationic radical oxidized key metabolic cofactor flavin adenine dinucleotide (FADH\n                    <jats:sub>2<\/jats:sub>\n                    ) to disrupt redox homeostasis and suppress fatty acid synthase (FASN)\u2010mediated metabolism. In contrast, control photosensitizers AQCN and AQNI bearing electron\u2010withdrawing substituents maintained singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) generation. Theoretical calculations revealed that AQTPE possessed a markedly reduced singlet\u2010triplet energy gap (\u0394\n                    <jats:italic>E<\/jats:italic>\n                    <jats:sub>ST<\/jats:sub>\n                    = 0.01\u00a0eV) and enhanced spin\u2010orbit coupling (7.538 cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), facilitating intersystem crossing. Notably, AQTPE nanoparticles exhibited potent type I photodynamic activity and robust tumor suppression even under hypoxic conditions. This study establishes a molecular electronegativity\u2010modulation framework for integrating electron reservoir\u2010pump systems within single\u2010component photosensitizers, offering a general design principle for next\u2010generation metabolism\u2010targeted and hypoxia\u2010tolerant photosensitizers.\n                  <\/jats:p>","DOI":"10.1002\/anie.9985126","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:10:39Z","timestamp":1777115439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anthraquinone\u2010Based Electron Reservoir\u2010Pump Photosensitizer Generating Radical Ion Pairs for Metabolism\u2010Targeted Photodynamic Therapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Tian","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible 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