{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:55Z","timestamp":1760188855102},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":6155,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the clinical and hematologic response to methotrexate (MTX) in 4 women with Felty's syndrome (FS) who had had neutropenia for 1\u20133 years. Since immune complexes or antineutrophil antibodies are implicated in the pathogenesis of the neutropenia of FS, we also measured both direct and indirect levels of neutrophil\u2010reactive IgG. All 4 patients showed a prompt and dramatic increase in neutrophil counts within 1\u20132 months of starting MTX therapy. In 3 patients, the symptoms of arthritis also improved; in the fourth patient, arthritis worsened. Recurring infections ceased in 3 patients. Neutrophil\u2010reactive IgG levels, which were elevated in all patients prior to treatment, decreased toward normal while the patients were receiving MTX therapy. We conclude that MTX is effective in treating the neutropenia of FS, in part by lowering neutrophil\u2010reactive IgG.<\/jats:p>","DOI":"10.1002\/anr.1780320212","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:40:01Z","timestamp":1171492801000},"page":"194-201","source":"Crossref","is-referenced-by-count":45,"title":["Reversal of neutropenia with methotrexate treatment in patients with felty's syndrome. Correlation of Response with Neutrophil\u2010Reactive IgG"],"prefix":"10.1002","volume":"32","author":[{"given":"Justus J.","family":"Fiechtner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Starkebaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"16","article-title":"Chronic arthritis in the adult, associated with splenomegaly and leucopenia: a report of five cases of an unusual clinical syndrome","volume":"395","author":"Felty AR","year":"1924","journal-title":"Johns Hopkins Hosp Bull"},{"key":"e_1_2_1_3_2","first-page":"156","article-title":"Felty's syndrome: an analytical review","volume":"141","author":"Spivak JL","year":"1977","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_4_2","first-page":"183","article-title":"Polymorphonuclear leukocyte inclusions and impaired bacterial killing in patients with Felty's syndrome","volume":"88","author":"Gupta RC","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.147.5.915"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.1.51"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109465"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260802"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-4-437"},{"key":"e_1_2_1_10_2","first-page":"307","article-title":"Humoral and cellular immune mechanisms of neutropenia in patients with Felty's syndrome","volume":"39","author":"Starkebaum G","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220702"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.8.696"},{"key":"e_1_2_1_13_2","first-page":"238","article-title":"Characterization of immune complexes and immuno\u2010globulin G antibodies reactive with neutrophils in the sera of patients with Felty's syndrome","volume":"96","author":"Starkebaum G","year":"1980","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archinte.1978.03630280059020","article-title":"Splenectomy for Felty's syndrome: clinicopathological study of 27 patients","volume":"138","author":"Laszlo J","year":"1978","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.5.486"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198603000-00003"},{"key":"e_1_2_1_17_2","first-page":"703","article-title":"D\u2010penicillamine in Felty's syndrome","volume":"12","author":"Lakhanpal S","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_18_2","first-page":"700","article-title":"High dose intravenous gamma globulin for Felty's syndrome","volume":"12","author":"Breedveld FC","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.146.2.277"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198601163140317"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503283121303"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-4-489"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/j.1875-9114.1986.tb03472.x","article-title":"Methotrexate in rheumatoid arthritis: an update","volume":"4","author":"Miller DR","year":"1986","journal-title":"Pharmacotherapy"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280702"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1182\/blood.V67.4.1126.1126","article-title":"Evaluation by quantitative acid elution and radioimmunoassay of multiple classes of immunoglobulins and serum albumin associated with platelets in idiopathic thrombocytopenic purpura","volume":"67","author":"Hotchkiss AJ","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108399"},{"key":"e_1_2_1_27_2","first-page":"888","article-title":"The latex fixation test. 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