{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T15:56:20Z","timestamp":1720626980869},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":6127,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The major rheumatoid factor cross\u2010reactive idiotype (RF\u2010CRI), defined by prototypic monoclonal IgM rheumatoid factors, is expressed in high frequency by pokeweed mitogen\u2013derived plasma cells from patients with rheumatoid arthritis who express RF in their sera. Unlike adults with rheumatoid arthritis, most patients with juvenile rheumatoid arthritis are seronegative for RF, as detected by classic IgG binding assays. We report that \u223c50% of seronegative patients with juvenile rheumatoid arthritis express the RF\u2010CRI in high frequency among their pokeweed mitogen\u2013derived plasma cells, and that \u223c33% of patients express the RF\u2010CRI in high titer in their sera. The possible mechanisms for expression of an idiotypic marker of RF without expression of IgG binding activity by classic assays are discussed.<\/jats:p>","DOI":"10.1002\/anr.1780320306","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:16:47Z","timestamp":1171495007000},"page":"265-270","source":"Crossref","is-referenced-by-count":12,"title":["Expression of the major rheumatoid factor cross\u2010reactive idiotype in juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"32","author":[{"given":"Norman T.","family":"Ilowite","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiah F.","family":"Wedgwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent R.","family":"Bonagura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.2.331"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110575"},{"key":"e_1_2_1_4_2","unstructured":"BonaguraVR WedgwoodJF AgostinoN HatamL MendezL JaffeI PernisB: Seronegative rheumatoid arthritis rheumatoid factor cross\u2010reactive idiotype: expression and hidden rheumatoid factor.Ann Rheum Dis(in press)"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112888"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109265"},{"key":"e_1_2_1_8_2","first-page":"260","article-title":"Serologic studies in juvenile rheumatoid arthritis: a review","volume":"20","author":"Petty RE","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_9_2","first-page":"165","article-title":"Juvenile rheumatoid arthritis: series 1","volume":"20","author":"Schaller JG","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.33.3.255"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210810"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241008"},{"key":"e_1_2_1_13_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(77)90065-5"},{"key":"e_1_2_1_15_2","first-page":"882","article-title":"The latex fixation test. 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