{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:27:00Z","timestamp":1760264820497},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":6096,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the proliferative responses of peripheral blood mononuclear cells (PBMC) to autologous and homologous muscle homogenates in 21 patients with early, active, untreated polymyositis\/dermatomyositis (PM\/DM), 8 patients with chronic PM\/DM, 10 patients with myopathies other than PM\/DM, 7 patients with connective tissue diseases without myositis, and 12 healthy individuals. PBMC from patients with PM\/DM and from control subjects were incubated with various dilutions of autologous and homologous muscle homogenates. PBMC from patients with active PM\/DM underwent significant proliferation on exposure to both the autologous muscle and the homologous muscle homogenates. In contrast, PBMC from patients with chronic PM\/DM, other myopathies, connective tissue diseases without myositis, and from healthy individuals did not respond to either autologous or homologous muscle. Our findings demonstrate that the PBMC of patients with PM\/DM are sensitized to muscle.<\/jats:p>","DOI":"10.1002\/anr.1780320414","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:16:09Z","timestamp":1171494969000},"page":"446-453","source":"Crossref","is-referenced-by-count":8,"title":["Proliferative response of peripheral blood mononuclear cells to autologous and allogeneic muscle in patients with polymyositis\/dermatomyositis"],"prefix":"10.1002","volume":"32","author":[{"given":"Apostolos E.","family":"Kalovidouris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachman","family":"Pourmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray H.","family":"Passo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoya","family":"Plotkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Polymyositis and dermatomyositis, Arthritis and Allied Conditions","author":"Kagen LJ","year":"1985"},{"key":"e_1_2_1_3_2","volume-title":"Inflammatory diseases of muscle, Textbook of Rheumatology","author":"Bradley WG","year":"1985"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.32.6.569"},{"key":"e_1_2_1_5_2","first-page":"63","article-title":"Immunological aspects of polymyositis","volume":"157","author":"Currie J","year":"1971","journal-title":"Q J Med"},{"key":"e_1_2_1_6_2","first-page":"25","article-title":"Lymphocyte sensitivity to skeletal muscle in patients with polymyositis and other disorders","volume":"14","author":"Esiri MM","year":"1973","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.6.521"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.34.3.353"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050802"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197300"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197707000-00001"},{"key":"e_1_2_1_12_2","volume-title":"Aid to the Investigation of Peripheral Nerve Injuries","author":"British Medical Research Council","year":"1943"},{"key":"e_1_2_1_13_2","first-page":"64","article-title":"Electrical activity of muscle in polymyositis","volume":"79","author":"Lambert EH","year":"1954","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_2_1_14_2","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"97","author":"Boyum A","year":"1968","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_1_15_2","first-page":"98","article-title":"Cellular immunity in ankylosing spondylitis: lack of response to spinal tissue antigens","volume":"10","author":"Kalovidouris AE","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_16_2","first-page":"283","article-title":"Characterization of T\u2010cell subset in peripheral blood and muscle in childhood dermatomyositis (abstract)","volume":"10","author":"Bresnan MJ","year":"1981","journal-title":"Ann Neurol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6386.181"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130413"},{"issue":"1","key":"e_1_2_1_19_2","first-page":"191","article-title":"Circulating T\u2010cell subsets in inflammatory myopathies (abstract)","volume":"34","author":"Lisak RP","year":"1984","journal-title":"Neurology"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90487-1"},{"key":"e_1_2_1_21_2","first-page":"260","article-title":"HLA\u2010B8 in polymyositis (letter)","volume":"298","author":"Behan WMH","year":"1978","journal-title":"N Engl J Med"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.5.2094"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/287855a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.1804"}],"container-title":["Arthritis &amp; 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