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Slopes of change over time, calculated for each organ system of each patient, failed to show significant differences between treatment groups. An immunosup\u2010pressive effect in the chlorambucil\u2010treated group was shown by decreases in the white blood cell counts (<jats:italic>P<\/jats:italic> = 0.02), platelet counts (<jats:italic>P<\/jats:italic> = 0.04), lymphocyte counts (<jats:italic>P<\/jats:italic> = 0.001), IgA\/IgM concentrations (<jats:italic>P<\/jats:italic> \u2264 0.05), and wheal size on mumps skin tests (<jats:italic>P<\/jats:italic> = 0.02). Three years of immunosuppressive treatment with chlorambucil did not benefit this scleroderma population.<\/jats:p>","DOI":"10.1002\/anr.1780320512","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:14:03Z","timestamp":1171494843000},"page":"584-593","source":"Crossref","is-referenced-by-count":90,"title":["Immunosuppression with chlorambucil, versus placebo, for scleroderma. 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