{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:21:33Z","timestamp":1715991693201},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":6035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We prepared antiidiotypic (anti\u2010Id) antibody to 2 polyclonal IgM rheumatoid factors (IgM\u2010RF) and 2 polyclonal \u201chidden\u201d IgM\u2010RF. The anti\u2010Id antibodies were isolated by chromatography on Sepharose 4B, to which was bound rabbit anti\u2010human IgG Fc fragments. F(ab\u2032)<jats:sub>2<\/jats:sub> fragments from the anti\u2010Id antibodies were generated by pepsin digestion and isolated by gel filtration. The anti\u2010Id antibodies directed against RF from 4 patients with juvenile rheumatoid arthritis (JRA) were tested by an inhibition hemolytic assay for crossreactivity with IgM\u2010RF from 4 adult patients with rheumatoid arthritis, 6 patients with JRA, and 13 JRA patients with hidden RF. The 4 anti\u2010Id antibodies had variable cross\u2010reactivity with the isolated adult RA RF, JRA RF, and JRA hidden RF. Similar results were obtained by a direct\u2010binding enzyme\u2010linked immunosorbent assay for the anti\u2010Id antibodies. The broad pattern of cross\u2010reactivity was apparently unrelated to a particular amino acid sequence, but was associated with the antigen\u2010binding site of IgM\u2010RF. These results suggest the possibility that the anti\u2010Id antibodies prepared against isolated RF obtained from JRA patients bear the \u201cinternal image\u201d of antigen; that is, the Fc region of human IgG. These anti\u2010Id antibodies may be generated in JRA patients and may possess specific immunomodulatory properties.<\/jats:p>","DOI":"10.1002\/anr.1780320607","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:13:14Z","timestamp":1171494794000},"page":"699-705","source":"Crossref","is-referenced-by-count":7,"title":["Cross\u2010reactive antiidiotypic antibodies against human rheumatoid factors from patients with juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"32","author":[{"given":"Terry L.","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Osborn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Dorner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"373","article-title":"Towards a network theory of the immune system","volume":"125","author":"Jerne NK","year":"1974","journal-title":"Ann Immunol (Paris)"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(87)90080-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.4049\/jimmunol.105.4.928","article-title":"Hidden rheumatoid factors reactivity with \u2018non\u2010a\u2019 and other antigens on native autologous IgG","volume":"105","author":"Gaardner PI","year":"1970","journal-title":"J Immunol"},{"key":"e_1_2_1_5_2","first-page":"733","article-title":"Specificity of rheumatoid factors cross\u2010reacting with human and rabbit IgG","volume":"82","author":"Gaardner PI","year":"1974","journal-title":"Acta Pathol Microbiol Immunol Scand (C)"},{"key":"e_1_2_1_6_2","first-page":"881","article-title":"The effects of chemical modification on the antigenicity of human and rabbit immunoglobulin G","volume":"30","author":"Hunneyball IM","year":"1976","journal-title":"Immunology"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241008"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.1.128"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.4049\/jimmunol.134.5.3281","article-title":"The majority of human monoclonal IgM rheumatoid factors express a \u201cprimary structure\u2010dependent\u201d cross\u2010reactive idiotype","volume":"134","author":"Chen PP","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.137.1.122"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.4049\/jimmunol.131.2.719","article-title":"The internal image of IgG in cross\u2010reactive anti\u2010idiotypic antibodies against human rheumatoid factors","volume":"131","author":"Fong S","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.4049\/jimmunol.132.3.1183","article-title":"Modulation of human rheumatoid factor\u2010specific lymphocyte responses with a cross\u2010reactive antiidiotype bearing the internal image of antigen","volume":"132","author":"Fong S","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.4049\/jimmunol.138.5.1391","article-title":"Rheumatoid factors from patients with rheumatoid arthritis possess private repertoires of idiotypes","volume":"138","author":"Nelson JL","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.3.155"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.136.2.477","article-title":"Expression of cross\u2010reactive idiotype on rheumatoid factor in patients with Sj\u00f6gren's syndrome","volume":"136","author":"Fox RI","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(83)90116-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1979.tb02732.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(81)90207-5"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109927"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210810"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198010000-00010"},{"key":"e_1_2_1_22_2","first-page":"134","article-title":"Enzymatic digestion of rabbit gammaglobulin and antibody and chromatography of digestion products","volume":"20","author":"Nisonoff A","year":"1964","journal-title":"Methods Med Res"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(88)80003-3"},{"key":"e_1_2_1_24_2","volume-title":"Regulatory idiotopes, Modern Concepts in Immunology","author":"Bona CA","year":"1987"},{"key":"e_1_2_1_25_2","first-page":"570","article-title":"The common occurrence of internal image type anti\u2010idiotypic antibodies in rabbits immunized with monoclonal and polyclonal human IgM rheumatoid factors","volume":"64","author":"Fong S","year":"1986","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.9.705"},{"key":"e_1_2_1_27_2","first-page":"177","article-title":"IgG antigens of C\u03b32 and C\u03b33 homology regions interacting with rheumatoid factors","volume":"12","author":"Natvig JB","year":"1972","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_28_2","first-page":"145","article-title":"The binding affinities of rheumatoid factors interacting with the C\u03b33 homology regions of human IgG","volume":"15","author":"Steward MW","year":"1973","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_29_2","first-page":"579","article-title":"Subfragmentation of the Fc fragment of human IgGl myeloma protein by thermolysin","volume":"30","author":"Hunneyball IM","year":"1976","journal-title":"Immunology"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1988.tb02436.x"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111097"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanr.1780320607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr.1780320607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T21:25:56Z","timestamp":1700688356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anr.1780320607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["10.1002\/anr.1780320607"],"URL":"https:\/\/doi.org\/10.1002\/anr.1780320607","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6]]}}}