{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:42:55Z","timestamp":1781304175900,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":6035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The benefit of high\u2010dose, pulse intravenous methylprednisolone (IVMP) for some patients with active lupus nephritis would appear paradoxical, since active nephritis is associated with profound abnormalities in Fc\u03b3 receptor function, and several studies have demonstrated that glucocorticoids decrease monocyte Fc\u03b3 receptor expression and phagocytic function. To resolve this paradox, we investigated the possibility that pulse IVMP might enhance monocyte Fc\u03b3 receptor function in patients with systemic lupus erythematosus (SLE). Circulating immune complex (CIC) levels, Fc\u03b3 receptor\u2013mediated clearance, and Fc\u03b3 receptor\u2013dependent monocyte function were analyzed in 23 SLE patients before and after pulse IVMP (1 gm daily for 3 days). A biphasic response in CIC levels, determined by a staphylococcal protein A binding assay, was observed. Initially, CIC levels increased within 2\u20134 hours after the first dose of pulse IVMP and then decreased by 50% within 24\u201348 hours after the completion of therapy. Fc\u03b3 receptor\u2013mediated binding and phagocytosis of IgG\u2010sensitized erythrocytes (EA) by monocytes in vitro were significantly enhanced 24 hours after the final dose of pulse IVMP (pre\u2010IVMP versus post\u2010IVMP 43 \u00b1 14% versus 53 \u00b1 12% EA rosettes, <jats:italic>P<\/jats:italic> &lt; 0.01; 3.00 \u00b1 1.04 versus 3.99 \u00b1 1.30 EA ingested\/monocyte, <jats:italic>P<\/jats:italic> &lt; 0.01). In contrast, there was no change in the phagocytosis of an Fc\u03b3 receptor\u2013independent probe, neuraminidasetreated erythrocytes. This enhancement of monocyte Fc\u03b3 receptor function may reflect a synergism between glucocorticoids and a suitably primed mononuclear phagocyte in SLE. Glucocorticoid\u2010induced augmentation of Fc\u03b3 receptor function in the presence of \u03b3\u2010interferon, which may be elevated in SLE, has been shown. The enhancement of monocyte Fc\u03b3 receptor function that we observed may contribute to the therapeutic efficacy of pulse IVMP in lupus nephritis.<\/jats:p>","DOI":"10.1002\/anr.1780320609","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:13:14Z","timestamp":1171494794000},"page":"717-725","source":"Crossref","is-referenced-by-count":16,"title":["High\u2010Dose, pulse intravenous methylprednisolone enhances fc\u03b3 receptor\u2013mediated mononuclear phagocyte function in systemic lupus erythematosus"],"prefix":"10.1002","volume":"32","author":[{"given":"Jane E.","family":"Salmon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Kapur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Meryhew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf A.","family":"Runquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Kimberly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197903083001002"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-4-526"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250108"},{"key":"e_1_2_1_5_2","first-page":"261","article-title":"Dynamics of mononuclear phagocyte system Fc receptor function in systemic lupus erythematosus: relation to disease activity and circulating immune complexes","volume":"51","author":"Kimberly RP","year":"1983","journal-title":"Clin Exp 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