{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:43:46Z","timestamp":1761155026534},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5974,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of reactive arthritis, a sterile inflammatory polyarthropathy that primarily affects HLA\u2013B27 positive individuals, has been associated with previous enteric infections caused by various gram\u2010negative bacteria. The possibility that a common bacterial epitope triggers the disease was investigated by screening a panel of documented arthritogenic <jats:italic>Shigella<\/jats:italic> strains as well as 2 epidemic\u2010associated nonarthritogenic <jats:italic>Shigella<\/jats:italic> controls. A 2\u2010Md plasmid specific to the arthritogenic strains was identified and sequenced. The plasmid encodes a number of small peptides that could be related to the development of reactive arthritis. Within 1 of these is a stretch of 5 consecutive amino acids, inferred from the DNA sequence and contained within an open reading frame, that is homologous to amino acid residues 71\u201375 of the polymorphic region of the \u03b11 domain of HLA\u2013B27. The data indicate that there is a bacterial plasmid common to arthritogenic <jats:italic>Shigella<\/jats:italic> strains that may play a role in triggering reactive arthritis. The finding that this plasmid encodes an epitope shared with HLA\u2013B27 suggests that molecular mimicry may play a role in the induction of this disease.<\/jats:p>","DOI":"10.1002\/anr.1780320802","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:12:48Z","timestamp":1171494768000},"page":"937-946","source":"Crossref","is-referenced-by-count":57,"title":["Identification of A 2\u2010Md plasmid from <i>shigella flexneri<\/i> associated with reactive arthritis"],"prefix":"10.1002","volume":"32","author":[{"given":"H.","family":"Stieglitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fosmire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lipsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"996","article-title":"Reiter's disease and HLA\u2010B27","author":"Brewerton DA","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_1_3_2","first-page":"607","article-title":"Identification of HLA\u2010B27M1 and \u2010M2 cross\u2010reactive antigens in Klebsiella, Shigella and Yersinia","volume":"52","author":"Van Bohemen CG","year":"1984","journal-title":"Immunology"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.4049\/jimmunol.139.9.3003","article-title":"A Yersinia pseudotuberculosis protein which cross\u2010reacts with HLA\u2010B27","volume":"139","author":"Chen JH","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.51.3.901-908.1986"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.4049\/jimmunol.140.10.3489","article-title":"Reaction of anti\u2010HLA\u2010B27 monoclonal antibodies with envelope proteins of Shigella species","volume":"140","author":"Raybourne RB","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_7_2","first-page":"969","article-title":"Reiter's syndrome following epidemic shigellosis","volume":"8","author":"Simon DG","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","first-page":"562","article-title":"Search for Reiter's syndrome after an outbreak of Shigella sonnei dysentery","volume":"6","author":"Kaslow RA","year":"1979","journal-title":"J Rheumatol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1128\/jb.74.4.461-476.1957","article-title":"Hybridization between Escherichia coli and Shigella","volume":"74","author":"Luria S","year":"1967","journal-title":"J Bacteriol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/7.6.1513"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(73)91149-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5463"},{"key":"e_1_2_1_13_2","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Maniatis T","year":"1982"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.116.2.1064-1066.1973"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_1_16_2","first-page":"837","article-title":"Fine specificity of HLA\u2010B27 cellular autorecognition","volume":"139","author":"Aparicio P","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_17_2","first-page":"964","article-title":"HLA antigens in Reiter's syndrome in Israeli patients","volume":"12","author":"Ben\u2010Chetrit E","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.18.120184.001133"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.38.100184.001205"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.21236\/ADB008856"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-619X(88)90006-6"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1984.tb01046.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.1.173"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(86)90081-2"},{"key":"e_1_2_1_25_2","first-page":"97","article-title":"A survey of isolates of Klebsiella pneumoniae which cross\u2010react with HLA\u2010B27\u2010associated cell\u2010surface structure on the lymphocytes of patients with ankylosing spondylitis","volume":"9","author":"Geczy AF","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.5.353"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/329506a0"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/329512a0"}],"container-title":["Arthritis &amp; 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