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Concentrations of the protein in the circulation, as studied by radioimmunoassay, were greatly elevated in patients with rheumatoid arthritis and polyarticular juvenile rheumatoid arthritis. In contrast, patients with reactive arthritis and oligoarticular juvenile rheumatoid arthritis, as well as rheumatoid arthritis patients treated with low\u2010dose glucocorticoids, had levels similar to those in healthy controls. The serum concentrations were not related to age. A patient with polychondritis and tracheal involvement had a high serum concentration of the protein, which decreased during plasma exchange and cyclo\u2010phosphamide treatment. Studies of the release of this cartilage matrix protein, which is present in nonarticular cartilage but not in articular cartilage, should aid in the understanding of the mechanisms of cartilage involvement in disease, and the protein may become a clinically useful marker.<\/jats:p>","DOI":"10.1002\/anr.1780320905","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:10:29Z","timestamp":1171494629000},"page":"1080-1086","source":"Crossref","is-referenced-by-count":43,"title":["Involvement of nonarticular cartilage, as demonstrated by release of a cartilage\u2010specific protein, in rheumatoid arthritis"],"prefix":"10.1002","volume":"32","author":[{"given":"Tore","family":"Saxne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Heineg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(84)80044-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1970367"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2070207"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2210623"},{"key":"e_1_2_1_6_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum"},{"key":"e_1_2_1_7_2","volume-title":"Yersinia arthritis and related disease: clinical and immunogenetic implications, Infection and Immunology in the Rheumatic Diseases","author":"Aho K","year":"1976"},{"key":"e_1_2_1_8_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0890114"},{"key":"e_1_2_1_10_2","volume-title":"Structure and metabolism of proteoglycans, Extracellular Matrix Biochemistry","author":"Heineg\u00e5rd D","year":"1984"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-022X(84)90040-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209102748"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300903"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281209"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanr.1780320905","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr.1780320905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T07:17:23Z","timestamp":1700723843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anr.1780320905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1989,9]]}},"alternative-id":["10.1002\/anr.1780320905"],"URL":"https:\/\/doi.org\/10.1002\/anr.1780320905","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,9]]}}}