{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:50:15Z","timestamp":1791838215958,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5913,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although antihistone antibodies are frequently detected in patients with systemic lupus erythematosus, they appear to be uncommon or present only at low levels in rheumatoid arthritis (RA) patients. We used an enzyme\u2010linked immunosorbent assay to study sera from 42 patients with RA, and we confirmed that antihistone antibodies mainly occurred at low levels in these patients. In contrast, 83% of 24 patients with Felty's syndrome had antihistone antibodies, often at high levels. Thus, antihistone antibodies may be a common autoimmune abnormality in patients with Felty's syndrome but not in other patients with RA. In addition, we demonstrated that some rheumatoid factors have cross\u2010reactive antihistone antibody activity.<\/jats:p>","DOI":"10.1002\/anr.1780321020","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:40:18Z","timestamp":1171492818000},"page":"1319-1324","source":"Crossref","is-referenced-by-count":25,"title":["Antihistone antibodies in rheumatoid arthritis and Felty's syndrome"],"prefix":"10.1002","volume":"32","author":[{"given":"Michael G.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"304","article-title":"The clinical application of an ELISA technique for the detection of antihistone antibodies","volume":"13","author":"Epstein A","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_3_2","volume-title":"Enzyme\u2010linked immunosorbent assay for anti\u2010DNA and antihistone antibodies, Manual of Clinical Laboratory Immunology","author":"Rubin RL","year":"1986"},{"key":"e_1_2_1_4_2","first-page":"934","article-title":"Profiles of antibodies to histones, DNA and IgG in patients with systemic rheumatic diseases determined by ELISA","volume":"12","author":"Gripenberg M","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_5_2","first-page":"722","article-title":"Antihistone antibodies detected by ELISA and immunoblotting in systemic lupus erythematosus and rheumatoid arthritis","volume":"13","author":"Costa O","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_6_2","first-page":"46","article-title":"Clinical features of systemic lupus erythematosus patients with antihistone antibodies","volume":"9","author":"Fritzler M","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230503"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280308"},{"key":"e_1_2_1_9_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(73)80797-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-3-369"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.5.287"},{"key":"e_1_2_1_13_2","first-page":"419","article-title":"Les anticorps anti\u2010histones au cours de la polyarthrite rhumato\u00efde","volume":"51","author":"Youinou P","year":"1984","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_1_14_2","first-page":"303","article-title":"Les anti\u2010corps anti\u2010histones de type IgG: valeur diagnostique au cours de la polyarthrite rhumato\u00efde, de la scl\u00e9rodermie, de la maladie lupique spontan\u00e9e et m\u00e9dicamenteuse","volume":"51","author":"Meyer O","year":"1984","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(85)90038-8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.6.1720"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830140114"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290106"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/275671a0"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanr.1780321020","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr.1780321020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T22:07:22Z","timestamp":1700777242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anr.1780321020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1002\/anr.1780321020"],"URL":"https:\/\/doi.org\/10.1002\/anr.1780321020","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10]]}}}