{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:46:31Z","timestamp":1759970791573,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":107,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Reports"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Myotonic dystrophy type 1 is the most common muscular dystrophy in adults. Anaesthetic management should take into consideration the numerous body systems affected, including the musculoskeletal; respiratory; cardiovascular; gastro\u2010intestinal; and central nervous systems. A 42\u2010year\u2010old man with myotonic dystrophy presented for septoplasty and bilateral inferior turbinate reductions. He had severe upper and lower extremity myotonia and weakness, pulmonary impairment with non\u2010obstructive patterns and first\u2010degree atrioventricular block with reduced ejection fraction. He used bilevel positive airway pressure, a cough assist device and was paced 3% of the time with a single\u2010chamber pacemaker. To reduce potential complications associated with opioid use and general anaesthetics, an opioid\u2010free technique was planned using local anaesthetic infiltration and sedation with a dexmedetomidine infusion. The patient maintained spontaneous ventilation and haemodynamic stability, and had an uneventful postoperative course. Dexmedetomidine is a highly selective \u03b12\u2010adrenergic receptor agonist that has the ability to provide sedation, analgesia and anxiolysis with a stable haemodynamic profile. Avoiding both opioids and general anaesthetics in these patients may decrease the risk of peri\u2010operative complications.<\/jats:p>","DOI":"10.1002\/anr3.12070","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T13:01:55Z","timestamp":1602853315000},"page":"135-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dexmedetomidine infusion for sedation in a patient with myotonic dystrophy*"],"prefix":"10.1002","volume":"8","author":[{"given":"A. Y.","family":"Liu","sequence":"first","affiliation":[{"name":"Michael G. DeGroote School of Medicine Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dower","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology McMaster University and Hamilton Health Sciences Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology McMaster University and Hamilton Health Sciences Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"volume-title":"GeneReviews","year":"1993","author":"Bird TD","key":"e_1_2_5_2_1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.94750"},{"key":"e_1_2_5_4_1","unstructured":"FerschlM MoxleyR DayJ GropperM.Practical suggestions for the anesthetic management of a myotonic dystrophy patient 2019.https:\/\/www.myotonic.org\/sites\/default\/files\/MDF_LongForm_AnesGuidelines_01C.pdf(accessed 03\/24\/2020)."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4282305"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-17410-1_11"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00243"},{"key":"e_1_2_5_8_1","first-page":"990","article-title":"Anesthetic management in a case of myotonic dystrophy with dexmedetomidine","volume":"58","author":"Yoshino T","year":"2009","journal-title":"Masui"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004885"},{"key":"e_1_2_5_10_1","first-page":"242","article-title":"Dexmedetomidine: its use in intensive care medicine and anaesthesia","volume":"16","author":"Scott\u2010Warren VL","year":"2016","journal-title":"British Journal of Anaesthesia Education"}],"container-title":["Anaesthesia Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.12070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anr3.12070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.12070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:22:25Z","timestamp":1759922545000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1002\/anr3.12070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/anr3.12070"],"URL":"https:\/\/doi.org\/10.1002\/anr3.12070","archive":["Portico"],"relation":{},"ISSN":["2637-3726","2637-3726"],"issn-type":[{"type":"print","value":"2637-3726"},{"type":"electronic","value":"2637-3726"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}