{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:00:24Z","timestamp":1759971624449,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":137,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>There has been a resurgence in the illicit use of 2,4\u2010dinitrophenol by people wishing to achieve rapid weight loss. Despite its availability, the drug is banned for human consumption as it is toxic and can have fatal consequences. We present the case of a 23\u2010year\u2010old man who regularly consumed 2,4\u2010dinitrophenol to generate fat loss without apparent ill effect. He was involved in a high\u2010speed road traffic collision and sustained limb\u2010threatening injuries. The combination of emergency surgery, trauma and 2,4\u2010dinitrophenol consumption culminated in deterioration under anaesthesia, with subsequent death from multiorgan failure in the intensive care unit 48\u00a0h later. Previous cases have reported death from 2,4\u2010dinitrophenol toxicity alone. We believe this is the first reported case of 2,4\u2010dinitrophenol toxicity triggered by the additional physiological stress of polytrauma and emergency surgery.<\/jats:p>","DOI":"10.1002\/anr3.12121","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T01:22:41Z","timestamp":1621387361000},"page":"106-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["2,4\u2010Dinitrophenol: \u2018diet\u2019 drug death following major trauma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-2149","authenticated-orcid":false,"given":"N.","family":"Freeman","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Moir","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lowis","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Public Health England.Hospitalisation and deaths linked to consumption of 2 4\u2010dinitrophenol (DNP). Medicines and Healthcare products Regulatory Agency.2019.https:\/\/www.cas.mhra.gov.uk\/ViewandAcknowledgment\/ViewAlert.aspx?AlertID=102864(accessed 01\/02\/2021)."},{"key":"e_1_2_5_3_1","unstructured":"Toxbase. Dinitrophenol (DNP).National Poisons Information Service.2018.https:\/\/www.toxbase.org\/Poisons\u2010Index\u2010A\u2010Z\/D\u2010Products\/DNP(accessed 01\/02\/2021)."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep033"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-011-0162-6"},{"key":"e_1_2_5_6_1","first-page":"249","article-title":"Diagnosis and management of malignant hyperthermia","volume":"17","author":"Gupta PK","year":"2017","journal-title":"British Journal of Anaesthesia Education"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12072"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkm008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/30.3.219"},{"key":"e_1_2_5_10_1","first-page":"251","article-title":"Dying to be thin: a dinitrophenol related fatality","volume":"46","author":"McFee RB","year":"2004","journal-title":"Veterinary and Human Toxicology"},{"key":"e_1_2_5_11_1","unstructured":"Agency for Toxic Substances and Disease Registry.Toxicological Profile for Dinitrophenols. CDC.2019.https:\/\/www.atsdr.cdc.gov\/toxprofiles\/tp.asp?id=729&tid=132(accessed 01\/02\/2021)."}],"container-title":["Anaesthesia Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.12121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anr3.12121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.12121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:12:16Z","timestamp":1759936336000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1002\/anr3.12121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/anr3.12121"],"URL":"https:\/\/doi.org\/10.1002\/anr3.12121","archive":["Portico"],"relation":{},"ISSN":["2637-3726","2637-3726"],"issn-type":[{"type":"print","value":"2637-3726"},{"type":"electronic","value":"2637-3726"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}