{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:48:55Z","timestamp":1759970935620,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We report a case of simultaneous malignant hyperthermia reactions occurring in two siblings during living donor liver transplantation. This report highlights the conflicting goals in the clinical management of liver transplantation and malignant hyperthermia, including the use of total intravenous anaesthesia and dantrolene in the face of the potential for drug\u2010induced hepatotoxicity in the remnant liver or transplanted liver graft, as well as cautious fluid management needed for liver transplantation balanced against the liberal fluid therapy required to prevent acute kidney injury associated with malignant hyperthermia. The logistical challenges of managing this emergency in two closely related patients are discussed, including rapid preparation of two vapour\u2010free anaesthesia machines, the need for availability of additional dantrolene and the requirement for additional personnel. Prompt recognition, immediate removal of the triggering agents and conversion to total intravenous anaesthesia helped to curtail the malignant hyperthermic reactions in our patients, both of whom made a full recovery.<\/jats:p>","DOI":"10.1002\/anr3.12145","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:03:10Z","timestamp":1643846590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simultaneous malignant hyperthermia reactions in two siblings during living donor liver transplantation"],"prefix":"10.1002","volume":"10","author":[{"given":"A.","family":"Majeed","sequence":"first","affiliation":[{"name":"Department of Anaesthesia King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Chaiah","sequence":"additional","affiliation":[{"name":"School of Medicine Alfaisal University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Latif","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Pakistan Kidney and Liver Institute and Research Centre Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tahir","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Prince Muhammad Bin Abdulaziz Hospital Madinah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010015\u20100310\u20101"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001878"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31818958e5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15317"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.09.036"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.02.023"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.12.003"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00671.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED-D-16-00186"}],"container-title":["Anaesthesia Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.12145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anr3.12145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.12145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:50:55Z","timestamp":1759924255000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1002\/anr3.12145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/anr3.12145"],"URL":"https:\/\/doi.org\/10.1002\/anr3.12145","archive":["Portico"],"relation":{},"ISSN":["2637-3726","2637-3726"],"issn-type":[{"type":"print","value":"2637-3726"},{"type":"electronic","value":"2637-3726"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-01-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12145"}}