{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:58:14Z","timestamp":1785351494820,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>POLG\u2010related mitochondrial disease is a rare mitochondrial disorder that is potentially associated with anaesthetic complications such as propofol\u2010related infusion syndrome. A 19\u2010year\u2010old man with mitochondrial DNA deletions and POLG\u2010related disorders presented for an elective robotic Heller\u2010Dor myotomy for the treatment of oesophageal pseudo\u2010achalasia associated with severe gastro\u2010oesophageal reflux. The fasting period was minimised to reduce the risk of metabolic stress. The anaesthetic technique included a rapid sequence induction with propofol and rocuronium, a remifentanil and sevoflurane\u2010based general anaesthesia with multimodal monitoring and peri\u2010operative lactate\u2010free intravenous fluids with added dextrose. The patient did not experience propofol\u2010related infusion syndrome but did have delayed tracheal extubation due to residual neuromuscular blockade requiring a second dose of sugammadex. This report demonstrates the safety of single\u2010use, low\u2010dose propofol in this patient group. Patients with POLG\u2010related mitochondrial disease may be at risk of prolonged neuromuscular blockade, and appropriate dosing of neuromuscular blocking agents with monitoring of neuromuscular blockade is strongly encouraged.<\/jats:p>","DOI":"10.1002\/anr3.12159","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T02:29:43Z","timestamp":1647224983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Peri\u2010operative management of an adult with POLG\u2010related mitochondrial disease"],"prefix":"10.1002","volume":"10","author":[{"given":"A.","family":"Valent","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Saint\u2010Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Delorme","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Saint\u2010Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Roland","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Saint\u2010Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lambe","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition Necker Enfants\u2010Malades Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sarnacki","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Necker Enfants\u2010Malades Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cattan","sequence":"additional","affiliation":[{"name":"Department of Surgery Saint\u2010Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Plaud","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Saint\u2010Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0101-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.1998.00725.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen014"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073816661458"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066610384195"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.107"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12158"},{"key":"e_1_2_5_9_1","first-page":"249","article-title":"A case of malignant hyperthermia with mitochondrial dysfunction (letter)","volume":"7","author":"Ohtani Y","year":"1985","journal-title":"Brain and Development"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199606000-00029"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03012149"}],"container-title":["Anaesthesia Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.12159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anr3.12159","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.12159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:50:53Z","timestamp":1759924253000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1002\/anr3.12159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/anr3.12159"],"URL":"https:\/\/doi.org\/10.1002\/anr3.12159","archive":["Portico"],"relation":{},"ISSN":["2637-3726","2637-3726"],"issn-type":[{"value":"2637-3726","type":"print"},{"value":"2637-3726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12159"}}