{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:47:59Z","timestamp":1759970879978,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":81,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cranioplasty, specifically a repair of the skull defect resulting from a previous decompressive craniectomy, is a relatively simple procedure associated with a minimal rate of complications. Even though seizures are seen in up to 30% of the patients postoperatively, status epilepticus is not commonly described. Cerebral oedema, ischaemia and neuro\u2010inflammation have been reported as putative causes of seizures in this population. Here, we report a case of refractory status epilepticus unresponsive to standard anti\u2010epileptic and anaesthetic agents. The use of dexmedetomidine helped terminate the episode and led to a favourable outcome. Most of the standard anti\u2010epileptic and anaesthetic agents act through potentiation of GABAergic transmission or sodium channel blockade and postsynaptic adrenoceptor activation by dexmedetomidine may help potentiate their effect. Further studies are needed to investigate its anticonvulsant effect on post\u2010traumatic brain injury and elaborate on optimal dosage.<\/jats:p>","DOI":"10.1002\/anr3.12246","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T13:38:54Z","timestamp":1695217134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of dexmedetomidine in post cranioplasty refractory status epilepticus"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6836-647X","authenticated-orcid":false,"given":"R.","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Sanjay Gandhi Postgraduate Institute of Medical Sciences and Research  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-8633","authenticated-orcid":false,"given":"A.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.12.016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2019.03.014"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.4.JNS172519"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11070846"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151620"},{"key":"e_1_2_5_7_1","first-page":"12","article-title":"Dexmedetomidine administration in a patient with status epilepticus under colour density spectral array monitoring","volume":"5","author":"Obara S","year":"2019","journal-title":"Journal of Anesthesia Clinical Reports"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-020-01753-x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03953.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7597-16.1.48"}],"container-title":["Anaesthesia Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.12246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:41:14Z","timestamp":1759923674000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1002\/anr3.12246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/anr3.12246"],"URL":"https:\/\/doi.org\/10.1002\/anr3.12246","archive":["Portico"],"relation":{},"ISSN":["2637-3726","2637-3726"],"issn-type":[{"type":"print","value":"2637-3726"},{"type":"electronic","value":"2637-3726"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2023-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12246"}}