{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T17:47:25Z","timestamp":1767030445385,"version":"3.48.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["code 001"],"award-info":[{"award-number":["code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/06180\u20107"],"award-info":[{"award-number":["2021\/06180\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Malignant hyperthermia is a potentially fatal autosomal dominant hypermetabolic pharmacogenetic syndrome resulting from altered intracellular calcium dynamics in skeletal muscle, triggered by halogenated anaesthetics and suxamethonium. Current evidence suggests a degree of association between malignant hyperthermia and joint dislocations. We evaluated 162 patients with a personal or family history of malignant hyperthermia utilising a standardised protocol. We found a significantly higher incidence of joint dislocations in patients with malignant hyperthermia compared to non\u2010susceptible patients (11% versus 0%, p\u2009=\u20090.002). This study contributes to understanding the long\u2010term clinical manifestations of malignant hyperthermia and consequently may help develop clinical management strategies which incorporate the risk of joint dislocations, such as care in positioning during anaesthesia, and therapeutic interventions to improve quality of life.<\/jats:p>","DOI":"10.1002\/anr3.70021","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T01:44:37Z","timestamp":1752111877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between joint dislocation and malignant hyperthermia"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4515-3508","authenticated-orcid":false,"given":"A. O.","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Neurology Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. V.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Neurology Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Neurology Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. S.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Genetics and Evolutionary Biology Institute of Biosciences, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S. B.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Neurology Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vainzof","sequence":"additional","affiliation":[{"name":"Department of Genetics and Evolutionary Biology Institute of Biosciences, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9372-7019","authenticated-orcid":false,"given":"H. C. A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43019-023-00189-z"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546503260788"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198870070-00015"},{"key":"e_1_2_6_5_1","unstructured":"https:\/\/www.msdmanuals.com\/professional\/injuries\u2010poisoning\/dislocations\/overview\u2010of\u2010dislocations(accessed 29\/04\/2024)."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev225"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0310-1"},{"key":"e_1_2_6_8_1","article-title":"Patellar dislocation: workup and decision\u2010making","volume":"15","author":"Samelis PV","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03011418"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-7094(13)70195-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.05.010"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.03105.x"},{"key":"e_1_2_6_13_1","first-page":"1993","volume-title":"GeneReviews\u00ae","author":"Hakim A","year":"2004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465000280040601"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-230018"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e41776"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0109-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-4597(08)60032-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-243"},{"key":"e_1_2_6_20_1","first-page":"351","article-title":"Shoulder dislocation after infraclavicular coracoid block","volume":"28","author":"Rodrguez J","year":"2003","journal-title":"Reg Anesth Pain Med"}],"container-title":["Anaesthesia Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.70021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T17:42:27Z","timestamp":1767030147000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1002\/anr3.70021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/anr3.70021"],"URL":"https:\/\/doi.org\/10.1002\/anr3.70021","archive":["Portico"],"relation":{},"ISSN":["2637-3726","2637-3726"],"issn-type":[{"type":"print","value":"2637-3726"},{"type":"electronic","value":"2637-3726"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70021"}}