{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:17:07Z","timestamp":1783516627151,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":102,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Ataxia with oculomotor apraxia type 2 is a rare autosomal recessive cerebellar ataxia caused by\n                    <jats:italic>senataxin<\/jats:italic>\n                    gene mutations, with minimal published data on anaesthetic management. We report the peri\u2010operative care of a 46\u2010year\u2010old woman with genetically confirmed ataxia with oculomotor apraxia type 2 undergoing laparoscopic cholecystectomy under general anaesthesia. Key challenges included uncertain sensitivity to neuromuscular blocking agents and the potential for respiratory weakness and bulbar dysfunction. Non\u2010technical challenges arose from incomplete recognition and communication of the condition pre\u2010operatively. Anaesthetic strategy prioritised titratable, reversible agents and careful intra\u2010operative monitoring. Rocuronium was administered in reduced dose with quantitative neuromuscular monitoring and fully reversed with sugammadex prior to tracheal extubation. Propofol, sevoflurane and remifentanil target\u2010controlled infusion were used to ensure haemodynamic stability and minimise cumulative opioid exposure. The patient recovered uneventfully with no residual weakness or respiratory impairment. To our knowledge, this is the first published description of general anaesthesia for laparoscopic surgery in a patient with ataxia with oculomotor apraxia type 2. It demonstrates that anaesthesia can be safely delivered to patients with this condition with careful pre\u2010operative planning.\n                  <\/jats:p>","DOI":"10.1002\/anr3.70061","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:15:52Z","timestamp":1776140152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["General anaesthesia for laparoscopic cholecystectomy in a patient with ataxia with oculomotor apraxia type 2"],"prefix":"10.1002","volume":"14","author":[{"given":"L.","family":"Steuart","sequence":"first","affiliation":[{"name":"Royal Alexandra Hospital  Paisley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Millar","sequence":"additional","affiliation":[{"name":"Royal Alexandra Hospital  Paisley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.7.958"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp211"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae239"},{"key":"e_1_2_5_5_1","unstructured":"National Ataxia Foundation.Ataxia with oculomotor apraxia (AOA).2016.https:\/\/www.ataxia.org.uk\/wp\u2010content\/uploads\/2020\/11\/AOA23a06.pdf(accessed 29\/03\/2026)."},{"key":"e_1_2_5_6_1","volume-title":"GeneReviews\u00ae [Internet]","author":"Moreira MC","year":"2004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010025\u201013277\u20109"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090\u20103801(09)60257\u20103"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkr020"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkr019"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15501"}],"container-title":["Anaesthesia Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.70061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anr3.70061","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.70061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:38:27Z","timestamp":1783514307000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1002\/anr3.70061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/anr3.70061"],"URL":"https:\/\/doi.org\/10.1002\/anr3.70061","archive":["Portico"],"relation":{},"ISSN":["2637-3726","2637-3726"],"issn-type":[{"value":"2637-3726","type":"print"},{"value":"2637-3726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-03-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70061"}}