{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:17:13Z","timestamp":1783516633510,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":166,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Neuroblastoma is the most common extracranial solid tumour in children and accounts for approximately 15% of paediatric cancer\u2010related deaths. Originating from the postganglionic sympathetic nervous system, it exhibits variable clinical behaviour. Catecholamine\u2010secreting neuroblastoma is an uncommon but relevant cause of severe hypertension in children and poses major anaesthetic challenges, particularly during induction and tumour manipulation. Evidence guiding peri\u2010operative blood pressure management in this context remains limited. Dravet syndrome is an encephalopathy characterised by early onset, temperature\u2010sensitive seizures, developmental impairment and drug resistance. Its management requires a tailored anaesthetic approach, as peri\u2010operative factors may lower the seizure threshold. We report the peri\u2010operative management of a 6\u2010year\u2010old child with Dravet syndrome who was diagnosed with a catecholamine\u2010secreting presacral\u00a0neuroblastoma. Pre\u2010operative optimisation included amlodipine, stepwise \u03b1\u2010blockade with phenoxybenzamine, subsequent \u03b2\u2010blockade with atenolol and volume expansion. The intra\u2010operative period was complicated by hypertension during tumour resection, preload\u2010related hypotension after prone positioning and hypotension due to arterial bleeding. Postoperatively, antihypertensive therapy was required for several months before discontinuation, and 18\u2009months after the surgery, the child returned to her normal lifestyle. This case combined two high\u2010risk anaesthesia scenarios: catecholamine\u2010mediated haemodynamic instability and a refractory epilepsy syndrome with temperature\u2010sensitive seizures.<\/jats:p>","DOI":"10.1002\/anr3.70075","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:33:56Z","timestamp":1781598836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri\u2010operative management of a child with catecholamine\u2010secreting neuroblastoma and Dravet syndrome undergoing tumour resection"],"prefix":"10.1002","volume":"14","author":[{"given":"L.","family":"Gisbert\u2010de la Cuadra","sequence":"first","affiliation":[{"name":"Ni\u00f1o Jes\u00fas University Children's Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Sifontes","family":"Romero","sequence":"additional","affiliation":[{"name":"Ni\u00f1o Jes\u00fas University Children's Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Ahijado Agudo","sequence":"additional","affiliation":[{"name":"Ni\u00f1o Jes\u00fas University Children's Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Palencia Calzada","sequence":"additional","affiliation":[{"name":"Ni\u00f1o Jes\u00fas University Children's Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"San Luis Arranz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Hospital Universitario de Canarias  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mart\u00ednez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Ni\u00f1o Jes\u00fas University Children's Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010023\u201006188\u20102"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318290c628"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8050395"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14673"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.16475"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000032709"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojim.2021.114018"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.06.027"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010023\u201006269\u20102"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102020\u2010234314"}],"container-title":["Anaesthesia Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.70075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anr3.70075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.70075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:38:39Z","timestamp":1783514319000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1002\/anr3.70075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/anr3.70075"],"URL":"https:\/\/doi.org\/10.1002\/anr3.70075","archive":["Portico"],"relation":{},"ISSN":["2637-3726","2637-3726"],"issn-type":[{"value":"2637-3726","type":"print"},{"value":"2637-3726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70075"}}