{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:38:34Z","timestamp":1792481914150,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":110,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100022419","name":"National Institute for Health Research Southampton Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022419","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The World Health Organisation recommends that all anaesthetised patients receive F\n                    <jats:sub>I<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    0.8 during surgery to reduce the risk of surgical site infections but did not consider the effect this might have on other clinical outcomes. A Cochrane systematic review concluded that insufficient evidence exists for routinely administering high oxygen concentrations intra\u2010operatively to reduce surgical site infections, and that doing so might increase mortality. A feasibility trial was conducted looking at the feasibility of controlling intra\u2010operative F\n                    <jats:sub>I<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and measuring systemic redox state. Here we explore further clinical outcomes from this study regarding postoperative complications and cognitive recovery. Twenty\u2010eight adult patients undergoing major abdominal surgery for cancer resection were randomly allocated to receive either conservative (F\n                    <jats:sub>I<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2009=\u20090.3, n\u2009=\u20098), typical (F\n                    <jats:sub>I<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2009=\u20090.55, n\u2009=\u200910) or recommended (F\n                    <jats:sub>I<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2009=\u20090.8, n\u2009=\u200910) oxygen throughout anaesthesia. Rates of radiologically reported atelectasis, cognitive recovery and infective postoperative morbidity were all collected up to 7\u2009days after surgery. Total intensive care unit length of stay was also recorded. Higher F\n                    <jats:sub>I<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    levels were associated with lower rates of atelectasis \u2010 6 (75%) versus 8 (80%) versus 3 (30%) for F\n                    <jats:sub>I<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2009=\u20090.30 versus 0.55 versus 0.80, respectively; p\u2009=\u20090.045. Postoperative cognitive recovery scores (0.7 (3.1) versus \u22120.1 (2.5) versus \u22121.8 (3.3), p\u2009=\u20090.277), Postoperative Morbidity Survey infection scores (5 (71%) versus 5 (56%) versus 3 (33%), p\u2009=\u20090.307) and intensive care unit length of stay (3 (2\u20134) versus 2.5 (2.00\u20133.75) versus 3 (2.00\u20135.25) days, p\u2009=\u20090.870) did not differ between groups. Changing the administered intra\u2010operative oxygen concentration may alter postoperative clinical outcomes, and adequately powered clinical studies are urgently needed to investigate the impact of this.\n                  <\/jats:p>","DOI":"10.1002\/anr3.70109","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:44:07Z","timestamp":1792478647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intra\u2010operative oxygen concentration could affect postoperative morbidity\u2014results of a randomised controlled feasibility trial (\n                    <scp>PULSE<\/scp>\n                    Ox)"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6257-207X","authenticated-orcid":false,"given":"A. F.","family":"Cumpstey","sequence":"first","affiliation":[{"name":"Peri\u2010operative and Critical Care Theme, NIHR Southampton Biomedical Research Centre University Hospital Southampton  Southampton UK"},{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Stygall","sequence":"additional","affiliation":[{"name":"Peri\u2010operative and Critical Care Theme, NIHR Southampton Biomedical Research Centre University Hospital Southampton  Southampton UK"},{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Clark","sequence":"additional","affiliation":[{"name":"Peri\u2010operative and Critical Care Theme, NIHR Southampton Biomedical Research Centre University Hospital Southampton  Southampton UK"},{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Minnion","sequence":"additional","affiliation":[{"name":"Peri\u2010operative and Critical Care Theme, NIHR Southampton Biomedical Research Centre University Hospital Southampton  Southampton UK"},{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Moyses","sequence":"additional","affiliation":[{"name":"Peri\u2010operative and Critical Care Theme, NIHR Southampton Biomedical Research Centre University Hospital Southampton  Southampton UK"},{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. S.","family":"Martin","sequence":"additional","affiliation":[{"name":"Peninsula Medical School University of Plymouth  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Peri\u2010operative and Critical Care Theme, NIHR Southampton Biomedical Research Centre University Hospital Southampton  Southampton UK"},{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Feelisch","sequence":"additional","affiliation":[{"name":"Peri\u2010operative and Critical Care Theme, NIHR Southampton Biomedical Research Centre University Hospital Southampton  Southampton UK"},{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.W.","family":"Grocott","sequence":"additional","affiliation":[{"name":"Peri\u2010operative and Critical Care Theme, NIHR Southampton Biomedical Research Centre University Hospital Southampton  Southampton UK"},{"name":"Clinical &amp; Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)30479\u20103"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012631.pub3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjao.2024.100277"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2025.04.020"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(16)30402\u20109"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.11.024"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.11.026"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd008884.pub2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.06.019"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2025.06.039"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102022\u2010070941"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13741\u2010019\u20100118\u2010y"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjao.2026.100563"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2006.12.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539\u2010199908000\u201000050"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.02.007"},{"key":"e_1_2_6_18_1","volume-title":"WAIS\u2010R manual","author":"Wechsler D","year":"1981"},{"key":"e_1_2_6_19_1","volume-title":"L'examen clinique en psychologie","author":"Rey A","year":"1964"},{"key":"e_1_2_6_20_1","volume-title":"Manual of directions and scoring","author":"Army Individual Test Battery","year":"1944"},{"key":"e_1_2_6_21_1","volume-title":"Multilingual aphasia examination","author":"Benton AL","year":"1989"},{"key":"e_1_2_6_22_1","volume-title":"A compendium of neuropsychological tests","author":"Spreen O","year":"1991"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713002535"},{"key":"e_1_2_6_24_1","volume-title":"Manual for the state\u2010trait anxiety inventory","author":"Spielberger C","year":"1983"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14584"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13741\u2010018\u20100098\u20103"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X19842245"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.11.003"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14786"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex128"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1452"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010011\u20100758\u20107"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1330"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.8.759"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.10.021"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017275"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/jnsbm.JNSBM_28_19"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2013.03.034"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103058"}],"container-title":["Anaesthesia Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.70109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anr3.70109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anr3.70109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:44:10Z","timestamp":1792478650000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1002\/anr3.70109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/anr3.70109"],"URL":"https:\/\/doi.org\/10.1002\/anr3.70109","archive":["Portico"],"relation":{},"ISSN":["2637-3726","2637-3726"],"issn-type":[{"value":"2637-3726","type":"print"},{"value":"2637-3726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70109"}}