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Achievement of this aim implies relatively large\u2010scale screening of women at an age of clinical significance through assay of biomarkers for disease present in blood or serum. Biosensor detection offers an attractive technology for the automated detection of such species. Among several biomarkers that have been identified that are present in patients with ovarian cancer, the only one that is commonly tested for in clinical use is cancer antigen 125, which is considered to be a poor biomarker for the disease. Here, we describe several biosensors that developed in the past decade for the detection of ovarian cancer biomarkers such as CA125, human epididymis protein 4 (HE4) and apolipoprotein A1. The challenges presented by the fabrication of biosensor devices for detecting ovarian cancer and the limited number of biosensors developed for this purpose are discussed.<\/jats:p>","DOI":"10.1002\/ansa.202400029","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T06:34:12Z","timestamp":1729751652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sensitive and Cost\u2010Effective Tools in the Detection of Ovarian Cancer Biomarkers"],"prefix":"10.1002","volume":"5","author":[{"given":"Anis","family":"Elhami","sequence":"first","affiliation":[{"name":"Dentistry faculty Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8939-3688","authenticated-orcid":false,"given":"Ahmad","family":"Mobed","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Soleimany","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Imam Reza Hospital Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalda","family":"Yazdani","sequence":"additional","affiliation":[{"name":"Immunology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmat Sadat","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Alzahra Hospital Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahya","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Student Research Committee School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Saffarfar","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Tehran Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Ovarian Cancer: Survival Statistics","author":"Navaneelan 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