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This study presents a novel, rapid and highly sensitive analytical method for quantifying a wide range of antineoplastic drugs and detecting other potentially harmful molecules on wiped surfaces. Utilizing hydrophilic interaction liquid chromatography (HILIC) coupled with high\u2010resolution spectrometry, the method combines the quantification of eight commonly used antineoplastic drugs: 5\u2010fluorouracil, ifosfamide, cyclophosphamide, gemcitabine, doxorubicin, methotrexate, epirubicin and irinotecan, with the identification of unknown compounds offering a comprehensive solution for monitoring hospital surface contamination. While HILIC\u2010MS\/MS has been extensively applied in various matrices, its use for surface contamination monitoring in healthcare settings has been relatively underexplored. Chromatographic separation was achieved using gradient elution on an HILIC ZORBAX 120 column (150\u00a0mm \u00d7 2.1\u00a0mm, 4\u00a0\u00b5m), enabling rapid analysis within 8 min. The method demonstrated exceptional sensitivity, achieving limits of quantification below 0.04\u00a0ng\/cm<jats:sup>2<\/jats:sup> for all targeted molecules. Applied to 28 surfaces in the day hospital of a medical oncology unit at a French hospital, the method revealed contamination on 22 surfaces with at least one antineoplastic drug. Additionally, unknown molecules, including a compound associated with cleaning detergents, were detected, highlighting the complexity of hospital surface contamination underscoring the ongoing risks faced by healthcare workers and patients. This innovative approach represents a significant advancement in analytical chemistry and hospital hygiene monitoring, providing a faster, more efficient and versatile alternative to traditional techniques, as it allows 5\u2010FU quantification within the same run time with other molecules. By addressing critical gaps in current methodologies, this study offers valuable insights into occupational safety and supports efforts to reduce exposure risks for healthcare workers and patients. Further research is needed to identify the unknown molecules detected and fully assess their potential risks.<\/jats:p>","DOI":"10.1002\/ansa.70004","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T06:32:51Z","timestamp":1741069971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Simultaneous Determination of Residual Contamination of Eight Antineoplastic on Surfaces by HILIC Chromatography Coupled to High\u2010Resolution Spectrometry"],"prefix":"10.1002","volume":"6","author":[{"given":"Zribi","family":"Kaouther","sequence":"first","affiliation":[{"name":"LR 12ES09 Faculty of Pharmacy of Monastir University of Monastir  Monastir Tunisia"},{"name":"Laboratory of Hygiene Hedi Chaker University Hospital  Sfax Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarra","family":"Berriri","sequence":"additional","affiliation":[{"name":"LR 12ES09 Faculty of Pharmacy of Monastir University of Monastir  Monastir Tunisia"},{"name":"Pharmacy Department Farhat Hached University Hospital Center  Sousse Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Libong","sequence":"additional","affiliation":[{"name":"Lipids, Analytical and Biological Systems University of Paris\u2010Saclay  Orsay France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Solgadi","sequence":"additional","affiliation":[{"name":"UMS\u2010IPSIT SAMM Facility Inserm CNRS Engineering and Platforms for Therapeutic Innovation UFR Pharmacy University of Paris\u2010Saclay  Orsay France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fathi","family":"Safta","sequence":"additional","affiliation":[{"name":"LR 12ES09 Faculty of Pharmacy of Monastir University of Monastir  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia Minh","family":"Mai L\u00ea","sequence":"additional","affiliation":[{"name":"Lipids, Analytical and Biological Systems University of Paris\u2010Saclay  Orsay France"},{"name":"Pharmacy Department European Georges Pompidou Hospital APHP Centre\u2014University of Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Caudron","sequence":"additional","affiliation":[{"name":"Lipids, Analytical and Biological Systems University of Paris\u2010Saclay  Orsay France"},{"name":"Pharmacy Department European Georges Pompidou Hospital APHP Centre\u2014University of Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"\u201cLatest Global Cancer Data: Cancer Burden Rises to 19.3 Million New Cases and 10.0 Million Cancer Deaths in 2020 \u201dIARC accessed March 16 2024 https:\/\/www.iarc.who.int\/featured\u2010news\/latest\u2010global\u2010cancer\u2010data\u2010cancer\u2010burden\u2010rises\u2010to\u201019\u20103\u2010million\u2010new\u2010cases\u2010and\u201010\u20100\u2010million\u2010cancer\u2010deaths\u2010in\u20102020\/."},{"key":"e_1_2_9_3_1","volume-title":"NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2016","author":"Connor T. 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