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Rapid and accurate quantification of RIB in real biological samples is important. In this study, a novel paper\u2010based electrochemical microsensor was fabricated for RIB detection in blood plasma samples. Highly conductive silver ink was synthesized and loaded into a ballpoint pen, enabling direct drawing of microscale (\u223c85.78\u00a0\u00b5m) electrodes onto a cellulose substrate. Owing to the optimized ink formulation, the drawn electrodes dried immediately (\u223c3\u00a0s) at room temperature, producing uniform, well\u2010defined and highly conductive patterns without spreading. In the presence of induced stress conditions, the electrodes exhibited excellent thermal, mechanical and moisture stability, with resistances remaining stable at 1.5\u00a0\u03a9 (at 150\u00b0C), 2.9\u00a0\u03a9 (humidity exposure) and 2\u00a0\u03a9 (mechanical bending). The three\u2010dimensional network formed by silver ink on photographic paper substrate preserved conductivity under stress and prevented structural cracking. RIB was detected using cyclic voltammetry, square\u2010wave voltammetry, chronoamperometry and differential pulse voltammetry. Under optimized conditions, the sensor showed a linear response over 0.4\u201310\u00a0\u00b5M with a lower limit of quantification of 0.4\u00a0\u00b5M. Intra\u2010day and inter\u2010day repeatability ranged from 1.47% to 6.35% and 3.4% to 8.04%, respectively.<\/jats:p>","DOI":"10.1002\/ansa.70069","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:46:11Z","timestamp":1773031571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monitoring of Metabolic Disorders Through Electro\u2010Sensing of Riboflavin by Novel Super\u2010Conductive Silver Ink Modified Paper"],"prefix":"10.1002","volume":"7","author":[{"given":"Rokhsareh","family":"Ebrahimi","sequence":"first","affiliation":[{"name":"Nutrition Research Center Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Asian Nano\u2010Ink (ANI) Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hasanzadeh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analysis Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-3686","authenticated-orcid":false,"given":"Nasrin","family":"Shadjou","sequence":"additional","affiliation":[{"name":"Department of Nanotechnology Faculty of Chemistry Urmia University  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1145104"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-016-9950-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114521005031"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27230B"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.012716"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.70109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa225"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030950"},{"issue":"1","key":"e_1_2_10_10_1","article-title":"Methods of Analysis of Riboflavin","volume":"23","author":"Abbas S. 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