{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:22:25Z","timestamp":1783110145411,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000857","name":"Loughborough University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Science Advances"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Misuse of performance\u2010enhancing substances in sport remains a persistent threat to the values of fair competition, with estimated doping prevalence far exceeding adverse analytical findings in routine testing. This highlights the need for improved surveillance tools capable of rapid and simple, on\u2010site screening methods. This proof\u2010of\u2010concept study evaluated atmospheric solids analysis probe\u2010mass spectrometry (ASAP\u2010MS) as a minimally complex, high\u2010throughput, and potentially deployable approach for detecting prohibited substances in black market products. Sixteen pharmaceutical products previously confirmed to contain prohibited substances were blind\u2010analysed using ASAP\u2010MS, alongside eleven third\u2010party batch\u2010tested sports supplements. Resultant multi\u2010channel spectra were interrogated manually for the presence of known precursor and product ions. In addition, a compound library was developed and applied using software\u2010driven matching. At least one prohibited substance was detected in all products without generating false positives in certified supplements. Manual spectral review identified only 68% of individual substances correctly. Initial issues with false positive detection of trenbolone in testosterone ester products using the software\u2010driven approach were iteratively optimised through alteration of match score thresholds. This achieved 96% correct substance identification and 100% detection for an adverse finding. Moreover, investigation of diagnostic precursor ions via heatmaps offered a complementary and additional reporting tool to reduce false negatives. This work demonstrated that ASAP\u2010MS, with tailored software\u2010driven analysis, provides reliable near\u2010real\u2010time qualitative screening of prohibited substances. More broadly, this supports the potential for portable, rapid mass spectrometry\u2010based screening platforms to strengthen forensic intelligence, accelerate anti\u2010doping investigations, and enhance athlete protection by complementing laboratory\u2010based confirmatory testing in sport.<\/jats:p>","DOI":"10.1002\/ansa.70088","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:20:43Z","timestamp":1777404043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Analysis of Sports Prohibited Substances in Black Market Pharmaceutical Products Using Atmospheric Solids Analysis Probe\u2010Mass Spectrometry"],"prefix":"10.1002","volume":"7","author":[{"given":"Alisha","family":"Henderson","sequence":"first","affiliation":[{"name":"School of Sport, Exercise and Health Sciences Loughborough University  Loughborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5517-7571","authenticated-orcid":false,"given":"Oliver","family":"Krug","sequence":"additional","affiliation":[{"name":"Centre for Preventive Doping Research Institute of Biochemistry German Sport University Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Sage","sequence":"additional","affiliation":[{"name":"Waters Corporation  Wilmslow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Douce","sequence":"additional","affiliation":[{"name":"Waters Corporation  Wilmslow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Campbell","sequence":"additional","affiliation":[{"name":"SpectralWorks Limited  Runcorn UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Moncur","sequence":"additional","affiliation":[{"name":"SpectralWorks Limited  Runcorn UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1535-6451","authenticated-orcid":false,"given":"Mario","family":"Thevis","sequence":"additional","affiliation":[{"name":"Centre for Preventive Doping Research Institute of Biochemistry German Sport University Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam M.","family":"Heaney","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Health Sciences Loughborough University  Loughborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010014\u20100247\u2010x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fspor.2024.1386539"},{"key":"e_1_2_11_4_1","unstructured":"World Anti\u2010Doping Agency.2023 Anti\u2010Doping Testing Figures. 2025 accessed February 10 2026 https:\/\/www.wada\u2010ama.org\/sites\/default\/files\/2025\u201006\/2023_anti_doping_testing_figures_en_0.pdf."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychsport.2018.05.004"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"118","article-title":"Abol Magd S. 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