{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:25:17Z","timestamp":1783542317043,"version":"3.55.0"},"reference-count":110,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Science Advances"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chloramphenicol (CAP) is an important broad\u2010spectrum antibiotic used to treat severe bacterial infections, but its clinical application is limited by serious toxic effects, including aplastic anaemia and bone marrow suppression. These care concerns underscore the need for fast, sensitive and reliable analytical methods for CAP detection in biological and food samples. In recent years, nanomaterial\u2010based biosensors have emerged as encouraging tools for this purpose, offering enhanced sensitivity, selectivity and analytical performance. This review examines recent advances in nanoscale detection of CAP using nanomaterial biosensors, with specific emphasis on nanomaterial\u2010based electrochemical platforms. The exceptional physicochemical properties of these materials, including enhanced electron transfer, large surface area, catalytic activity and signal amplification, have contributed to the development of highly effective sensing systems. These biosensors have shown strong potential for rapid analysis and trace detection in complex matrices. Moreover, several challenges remain before these platforms can be fully translated into routine clinical and regulatory use. Subjects such as matrix effects, reproducibility, stability and validation against reference methods require further attention. This review critically discusses current progress, highlights the limitations of existing approaches and outlines future directions for the development of practical laboratory\u2010based biosensing approaches for CAP detection.<\/jats:p>","DOI":"10.1002\/ansa.70093","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:38:51Z","timestamp":1783539531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Laboratory Innovations: Nanoscale Detection of Chloramphenicol Using Nanomaterial Biosensors"],"prefix":"10.1002","volume":"7","author":[{"given":"Nava Moghadasian","family":"Niaki","sequence":"first","affiliation":[{"name":"Women's Reproductive Health Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Kheradmand","sequence":"additional","affiliation":[{"name":"The Faculty of Medical Sciences at the Islamic Azad University  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Giso","family":"Akbarian","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Shaterian","sequence":"additional","affiliation":[{"name":"The Faculty of Medical Sciences at the Islamic Azad University  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Shaterian","sequence":"additional","affiliation":[{"name":"The Faculty of Medical Sciences at the Islamic Azad University  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Mobed","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Social Determinants of Health Research Center, Health Management and Safety Promotion Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.talo.2025.100561","article-title":"Advancement in Electrochemical Sensing of Chloramphenicol in Varying Matrixes: A Review","volume":"12","author":"Mulaudji K. P.","year":"2025","journal-title":"Talanta Open"},{"issue":"1","key":"e_1_2_16_3_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40985-018-0099-2","article-title":"Food Safety Impacts of Antimicrobial Use and Their Residues in Aquaculture","volume":"39","author":"Okocha R.","year":"2018","journal-title":"Public Health Reviews"},{"key":"e_1_2_16_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117694","article-title":"Wireless & Portable Smartphone Assisted Electrochemical Platform for On\u2010Site Monitoring of Chloramphenicol Drug","volume":"287","author":"Dogra P.","year":"2025","journal-title":"Biosensors and Bioelectronics"},{"key":"e_1_2_16_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.135434","article-title":"Determination of Chloramphenicol in Food Using Nanomaterial\u2010Based Electrochemical and Optical Sensors\u2010A Review","volume":"410","author":"Sun Y.","year":"2023","journal-title":"Food Chemistry"},{"issue":"10","key":"e_1_2_16_6_1","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1002\/fsn3.2530","article-title":"Determination of Chloramphenicol in Meat Samples Using Liquid Chromatography\u2013Tandem Mass Spectrometry","volume":"9","author":"Akter Mou S.","year":"2021","journal-title":"Food Science & Nutrition"},{"issue":"5","key":"e_1_2_16_7_1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3390\/separations10050300","article-title":"Recent Advances in Using Adsorbent Derived From Agricultural Waste for Antibiotics and Non\u2010Steroidal Anti\u2010Inflammatory Wastewater Treatment: A Review","volume":"10","author":"Nordin A. H.","year":"2023","journal-title":"Separations"},{"key":"e_1_2_16_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.106687","article-title":"Dietary Anti\u2010Inflammatory and Anti\u2010Bacterial Medicinal Plants and Its Compounds in Bovine Mastitis Associated Impact on Human Life: A Comprehensive Review","volume":"192","author":"Nelson V. K.","year":"2024","journal-title":"Microbial Pathogenesis"},{"issue":"2","key":"e_1_2_16_9_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/19440049.2024.2435326","article-title":"Comparative Assessment of Commercial ELISA Kits for the Screening of Chloramphenicol Residues in Meat and Aquaculture Products According to European Regulation (EU) 2021\/808 and to the New Reference Point for Action (Commission Regulation (EU) 2019\/1871)","volume":"42","author":"Rousseau L.","year":"2025","journal-title":"Food Additives & Contaminants: Part A"},{"issue":"17","key":"e_1_2_16_10_1","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1039\/D2AY00291D","article-title":"Rapid Quantitative Detection of Chloramphenicol in Three Food Products by Lanthanide\u2010Labeled Fluorescent\u2010Nanoparticle Immunochromatographic Strips","volume":"14","author":"Lu C.","year":"2022","journal-title":"Analytical Methods"},{"key":"e_1_2_16_11_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cca.2022.06.027","article-title":"Biosensors Technology for Anti\u2010Epileptic Drugs","volume":"533","author":"Mobed A.","year":"2022","journal-title":"Clinica Chimica Acta"},{"key":"e_1_2_16_12_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cca.2021.03.009","article-title":"Biosensors in Parkinson's Disease","volume":"518","author":"Mobed A.","year":"2021","journal-title":"Clinica Chimica Acta"},{"key":"e_1_2_16_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cplett.2022.140195","article-title":"Theoretical Speculation on the Chemical Reaction Activity Site and Degradation Mechanism of Chloramphenicol","volume":"811","author":"Wang H.","year":"2023","journal-title":"Chemical Physics Letters"},{"issue":"42","key":"e_1_2_16_14_1","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202303396","article-title":"Azide\u2010Free Enantioselective Synthesis of Clinical Antibiotic (1R, 2R)\u2010Chloramphenicol (Chloromycetin)","volume":"8","author":"Bhamboo P.","year":"2023","journal-title":"ChemistrySelect"},{"key":"e_1_2_16_15_1","doi-asserted-by":"crossref","first-page":"23582","DOI":"10.1007\/s11356-020-09756-3","article-title":"Chemical and Toxicological Evaluation Along With Unprecedented Transformation Products During Photolysis and Heterogeneous Photocatalysis of Chloramphenicol in Different Aqueous Matrices","volume":"28","author":"Marson E. O.","year":"2021","journal-title":"Environmental Science and Pollution Research"},{"issue":"1","key":"e_1_2_16_16_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10409238309102789","article-title":"Chloramphenicol Acetyltransferase: Enzymology and Molecular Biology","volume":"14","author":"Shaw W.","year":"1983","journal-title":"Critical Reviews in Biochemistry"},{"issue":"2","key":"e_1_2_16_17_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/antibiotics5020020","article-title":"Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions","volume":"5","author":"Dinos G.","year":"2016","journal-title":"Antibiotics"},{"issue":"1","key":"e_1_2_16_18_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/antibiotics8010009","article-title":"New Chloramphenicol Derivatives From the Viewpoint of Anticancer and Antimicrobial Activity","volume":"8","author":"Giannopoulou P. C.","year":"2019","journal-title":"Antibiotics"},{"key":"e_1_2_16_19_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.141474","article-title":"Fabrication of MnSnO2 Intercalated TA\u2010rGO Modified Sensor for Selective Electrochemical Detection of Chloramphenicol in Real Samples","volume":"464","author":"Hsiao W.","year":"2025","journal-title":"Food Chemistry"},{"issue":"2","key":"e_1_2_16_20_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00003-025-01549-5","article-title":"Probabilistic and Deterministic Risk Assessment of Chloramphenicol Residues in Broiler Chicken Meat","volume":"20","author":"Pipoyan D.","year":"2025","journal-title":"Journal of Consumer Protection and Food Safety"},{"issue":"11","key":"e_1_2_16_21_1","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1039\/D4NJ05369A","article-title":"Rapid Detection and Visible Light Driven Photocatalytic Degradation of Chloramphenicol in Aqueous Medium Using a CoAl2O4\/rGO Nanocomposite","volume":"49","author":"Kaur K.","year":"2025","journal-title":"New Journal of Chemistry"},{"issue":"1","key":"e_1_2_16_22_1","doi-asserted-by":"crossref","DOI":"10.1128\/aem.01547-22","article-title":"Molecular Mechanism of Chloramphenicol and Thiamphenicol Resistance Mediated by a Novel Oxidase, CmO, in Sphingomonadaceae","volume":"89","author":"Ma X.","year":"2023","journal-title":"Applied and Environmental Microbiology"},{"key":"e_1_2_16_23_1","volume-title":"Introduction to Basics of Pharmacology and Toxicology: Volume 2: Essentials of Systemic Pharmacology: From Principles to Practice","author":"Anandabaskar N.","year":"2021"},{"key":"e_1_2_16_24_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.816398","article-title":"Functions and Regulation of Translation Elongation Factors","volume":"8","author":"Xu B.","year":"2022","journal-title":"Frontiers in Molecular Biosciences"},{"issue":"19","key":"e_1_2_16_25_1","doi-asserted-by":"crossref","first-page":"10807","DOI":"10.1093\/nar\/gkab288","article-title":"Uniform Affinity\u2010Tuning of N\u2010Methyl\u2010Aminoacyl\u2010tRNAs to EF\u2010Tu Enhances Their Multiple Incorporation","volume":"49","author":"Iwane Y.","year":"2021","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_16_26_1","volume-title":"Chloramphenicol","author":"Stanley Oiseth L.","year":"2025"},{"issue":"1","key":"e_1_2_16_27_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.aca.2004.08.035","article-title":"Development and Validation of Screening and Confirmatory Methods for the Detection of Chloramphenicol and Chloramphenicol Glucuronide Using SPR Biosensor and Liquid Chromatography\u2013Tandem Mass Spectrometry","volume":"529","author":"Ashwin H.","year":"2005","journal-title":"Analytica Chimica Acta"},{"issue":"4","key":"e_1_2_16_28_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ram.2019.01.002","article-title":"Five\u2010Assay Microbiological System for the Screening of Antibiotic Residues","volume":"51","author":"Tumini M.","year":"2019","journal-title":"Revista Argentina de Microbiolog\u00eda"},{"issue":"2","key":"e_1_2_16_29_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/separations13020046","article-title":"Separation Strategies for Polyphenols From Plant Extracts: Advances, Challenges, and Applications","volume":"13","author":"Savic S.","year":"2026","journal-title":"Separations"},{"issue":"10","key":"e_1_2_16_30_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3390\/toxics13100867","article-title":"Analytical Methods for the Determination of Diamorphine (Heroin) in Biological Matrices: A Review","volume":"13","author":"Al\u2010Asmari A.","year":"2025","journal-title":"Toxics"},{"issue":"10","key":"e_1_2_16_31_1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1080\/00032710902954482","article-title":"Analyses of Chloramphenicol in Biological Samples by HPLC","volume":"42","author":"Ali I.","year":"2009","journal-title":"Analytical Letters"},{"issue":"3","key":"e_1_2_16_32_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/22297928.2013.806413","article-title":"Analysis of Chloramphenicol in Biological Samples by SPE\u2010HPLC","volume":"3","author":"Ali I.","year":"2013","journal-title":"Analytical Chemistry Letters"},{"issue":"2","key":"e_1_2_16_33_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.5455\/javar.2018.e257","article-title":"Screening of Antibiotic Residues in Chicken Meat in Bangladesh by Thin Layer Chromatography","volume":"5","author":"Sarker Y.","year":"2018","journal-title":"Journal of Advanced Veterinary and Animal Research"},{"issue":"6","key":"e_1_2_16_34_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/10826076.2018.1448689","article-title":"Development of Quantitative HPTLC\u2010Densitometry Methods Following a Model Approach for Transfer of TLC Screening Methods for Pharmaceutical Products of Atenolol, Chloramphenicol, Furosemide, Glibenclamide, Penicillin V Potassium, and Praziquantel","volume":"41","author":"Zeng B.","year":"2018","journal-title":"Journal of Liquid Chromatography & Related Technologies"},{"issue":"1","key":"e_1_2_16_35_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/jssc.201800625","article-title":"Recent Advances in the Preparation of Adsorbent Layers for Thin\u2010Layer Chromatography Combined With Matrix\u2010Assisted Laser Desorption\/Ionization Mass\u2010Spectrometric Detection","volume":"42","author":"Kucherenko E.","year":"2019","journal-title":"Journal of Separation Science"},{"issue":"11","key":"e_1_2_16_36_1","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.3390\/pr13113497","article-title":"TLC in the Analysis of Plant Material","volume":"13","author":"Zych M.","year":"2025","journal-title":"Processes"},{"issue":"2","key":"e_1_2_16_37_1","doi-asserted-by":"crossref","DOI":"10.1111\/jfs.12759","article-title":"Sensitive Enzyme\u2010Linked Immunosorbent Assay and Gold Nanoparticle Immunochromatocgraphic Strip for Rapid Detecting Chloramphenicol in Food","volume":"40","author":"Wu S.","year":"2020","journal-title":"Journal of Food Safety"},{"issue":"1","key":"e_1_2_16_38_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3126\/on.v15i1-2.18789","article-title":"ELISA Validation and Determination of Cut\u2010Off Level for Chloramphenicol (CAP) Residues in Shrimp and Fish","volume":"15","author":"Sarwer M. G.","year":"2017","journal-title":"Our Nature"},{"issue":"14","key":"e_1_2_16_39_1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jchromb.2009.03.040","article-title":"Determination of Chloramphenicol, Thiamphenicol, Florfenicol, and Florfenicol Amine in Poultry and Porcine Muscle and Liver by Gas Chromatography\u2010Negative Chemical Ionization Mass Spectrometry","volume":"877","author":"Shen J.","year":"2009","journal-title":"Journal of Chromatography B"},{"issue":"1","key":"e_1_2_16_40_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6904-9-1","article-title":"Application of Microbiological Assay to Determine Pharmaceutical Equivalence of Generic Intravenous Antibiotics","volume":"9","author":"Zuluaga A. F.","year":"2009","journal-title":"BMC Clinical Pharmacology"},{"issue":"6","key":"e_1_2_16_41_1","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.3390\/app16062962","article-title":"Development and Validation of RP\u2010HPLC Method for Simultaneous Assay and Dissolution Quantitative Analysis of Pitavastatin\u2010Fenofibrate Complex Dual\u2010Layered Tablets","volume":"16","author":"Kim D.","year":"2026","journal-title":"Applied Sciences"},{"key":"e_1_2_16_42_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.132937","article-title":"Effect\u2010Directed Analysis in Food by Thin\u2010Layer Chromatography Assays","volume":"390","author":"Cabezudo I.","year":"2022","journal-title":"Food Chemistry"},{"key":"e_1_2_16_43_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-0716-2376-3_10","volume-title":"Cancer Cell Biology: Methods and Protocols","author":"Tabatabaei M. S.","year":"2022"},{"issue":"8","key":"e_1_2_16_44_1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.steroids.2007.05.003","article-title":"Superiority of Gas Chromatography\/Tandem Mass Spectrometry Assay (GC\/MS\/MS) for Estradiol for Monitoring of Aromatase Inhibitor Therapy","volume":"72","author":"Santen R. J.","year":"2007","journal-title":"Steroids"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios12080647"},{"issue":"16","key":"e_1_2_16_46_1","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1039\/C9TB02189B","article-title":"Biosensors and Bioassays for Determination of Matrix Metalloproteinases: State of the Art and Recent Advances","volume":"8","author":"Lei Z.","year":"2020","journal-title":"Journal of Materials Chemistry B"},{"key":"e_1_2_16_47_1","volume-title":"Determination of Antibiotic Residues in Milk Produced at High Altitude Regions of Himachal Pradesh and Its Public Health Significance","author":"NEGI R.","year":"2024"},{"key":"e_1_2_16_48_1","volume-title":"Microbial Determination Methods in Pharmaceutical and Food Quality Control","author":"Das A.","year":"2023"},{"key":"e_1_2_16_49_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jim.2023.113604","article-title":"Novel Hapten Design, Highly Sensitive Monoclonal Antibody Production, and Immunoassay Development for Rapid Screening of Illegally Added Chloramphenicol in Cosmetics","volume":"525","author":"Wang Z.","year":"2024","journal-title":"Journal of Immunological Methods"},{"issue":"22","key":"e_1_2_16_50_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262211181","article-title":"Enhanced Antibacterial and Anti\u2010Inflammatory Activities of the Combination of Cannabis sativa and Propolis Extracts: An In Vitro Study","volume":"26","author":"Perstwong N.","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"e_1_2_16_51_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.56557\/ajocr\/2023\/v8i48441","article-title":"A Review of Global Occurrence of Emerging Pollutants in Wastewater: Present Status, Source\/Pathway, Extraction and Detection Techniques","volume":"8","author":"Shehu Z.","year":"2023","journal-title":"Asian Journal of Current Research"},{"key":"e_1_2_16_52_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfp.2026.100733","article-title":"Chloramphenicol Contamination in Milk: Measurement, Methods, and Regulatory: A Systematic Review","volume":"89","author":"Mohamadi B.","year":"2026","journal-title":"Journal of Food Protection"},{"key":"e_1_2_16_53_1","doi-asserted-by":"crossref","first-page":"10381","DOI":"10.1021\/acsanm.6c01553","article-title":"Selective Detection of Chloramphenicol Using Electroactive Azo\u2010Bridged Porous Organic Polymers","volume":"9","author":"Kapoor A.","year":"2026","journal-title":"ACS Applied Nano Materials"},{"key":"e_1_2_16_54_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.sintl.2021.100100","article-title":"Biosensors Applications in Medical Field: A Brief Review","volume":"2","author":"Haleem A.","year":"2021","journal-title":"Sensors International"},{"key":"e_1_2_16_55_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117308","article-title":"Surface Plasmon Resonance Biosensors and Their Medical Applications","volume":"278","author":"\u0160pringer T.","year":"2025","journal-title":"Biosensors and Bioelectronics"},{"issue":"1","key":"e_1_2_16_56_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/molecules27010165","article-title":"Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring","volume":"27","author":"Pillai S.","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"e_1_2_16_57_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/bios13010040","article-title":"Nanotechnology\u2010Enabled Biosensors: A Review of Fundamentals, Design Principles, Materials, and Applications","volume":"13","author":"Ramesh M.","year":"2022","journal-title":"Biosensors"},{"key":"e_1_2_16_58_1","volume-title":"Biosensors: Developments, Challenges and Perspectives","author":"Priya S.","year":"2024"},{"key":"e_1_2_16_59_1","volume-title":"Annales Pharmaceutiques Fran\u00e7aises","author":"Pawnikar V.","year":"2025"},{"issue":"4","key":"e_1_2_16_60_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.asems.2023.100081","article-title":"Electrochemical Biosensors Represent Promising Detection Tools in Medical Field","volume":"2","author":"Zhang L.","year":"2023","journal-title":"Advanced Sensor and Energy Materials"},{"key":"e_1_2_16_61_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.hybadv.2023.100023","article-title":"Recent Advances in Electrochemical Biosensors\u2013A Brief Review","volume":"2","author":"Sumitha M.","year":"2023","journal-title":"Hybrid Advances"},{"key":"e_1_2_16_62_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113805","article-title":"Recent Advancements in Optical Biosensors for Cancer Detection","volume":"197","author":"Kaur B.","year":"2022","journal-title":"Biosensors and Bioelectronics"},{"key":"e_1_2_16_63_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mee.2021.111523","article-title":"An Integrated Electro\u2010Optical Biosensor System for Rapid, Low\u2010Cost Detection of Bacteria","volume":"239","author":"Petrovszki D.","year":"2021","journal-title":"Microelectronic Engineering"},{"key":"e_1_2_16_64_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.sna.2024.115664","article-title":"Piezoelectric Biosensor Based on Ultrasensitive MEMS System","volume":"376","author":"He J.","year":"2024","journal-title":"Sensors and Actuators A: Physical"},{"key":"e_1_2_16_65_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbsr.2022.100510","article-title":"Piezoelectric Point\u2010of\u2010Care Biosensor for the Detection of SARS\u2010COV\u20102 (COVID\u201019) Antibodies","volume":"37","author":"Mandal D.","year":"2022","journal-title":"Sensing and Bio\u2010Sensing Research"},{"issue":"9","key":"e_1_2_16_66_1","doi-asserted-by":"crossref","first-page":"15175","DOI":"10.1021\/acsnano.2c06481","article-title":"Metal\u2013Organic Framework\u2010Based Biosensor for Detecting Hydrogen Peroxide in Plants Through Color\u2010to\u2010Thermal Signal Conversion","volume":"16","author":"Yan Y.","year":"2022","journal-title":"ACS Nano"},{"key":"e_1_2_16_67_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113586","article-title":"Thermal Self\u2010Regulatory Intelligent Biosensor Based on Carbon\u2010Nanotubes\u2010Decorated Phase\u2010Change Microcapsules for Enhancement of Glucose Detection","volume":"195","author":"Sun Z.","year":"2022","journal-title":"Biosensors and Bioelectronics"},{"key":"e_1_2_16_68_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceja.2023.100516","article-title":"Fundamentals of Bio\u2010Electrochemical Sensing","volume":"16","author":"Shanbhag M. M.","year":"2023","journal-title":"Chemical Engineering Journal Advances"},{"issue":"3","key":"e_1_2_16_69_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10544-023-00666-y","article-title":"Biosensors; Noninvasive Method in Detection of C\u2010Reactive Protein (CRP)","volume":"25","author":"Khanmiri H. H.","year":"2023","journal-title":"Biomedical Microdevices"},{"key":"e_1_2_16_70_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cca.2020.05.025","article-title":"Bioassay: A Novel Approach in Antipsychotic Pharmacology","volume":"509","author":"Mobed A.","year":"2020","journal-title":"Clinica Chimica Acta"},{"issue":"8","key":"e_1_2_16_71_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/chemosensors11080467","article-title":"Progress on Electrochemical Sensing of Pharmaceutical Drugs in Complex Biofluids","volume":"11","author":"Fu E.","year":"2023","journal-title":"Chemosensors"},{"key":"e_1_2_16_72_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.12688\/f1000research.130863.1","article-title":"Biosensors for Therapeutic Drug Monitoring: A Review","volume":"12","author":"Shalannanda W.","year":"2023","journal-title":"F1000Research"},{"issue":"14","key":"e_1_2_16_73_1","doi-asserted-by":"crossref","DOI":"10.1002\/asia.202200287","article-title":"Recent Advances in Nanomaterial\u2010Based Optical Biosensors as Potential Point\u2010of\u2010Care Testing (PoCT) Probes in Carcinoembryonic Antigen Detection","volume":"17","author":"Ng S. S.","year":"2022","journal-title":"Chemistry\u2013An Asian Journal"},{"issue":"11","key":"e_1_2_16_74_1","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/anae.15834","article-title":"Novel Wearable and Contactless Heart Rate, Respiratory Rate, and Oxygen Saturation Monitoring Devices: A Systematic Review and Meta\u2010Analysis","volume":"77","author":"Chan P. Y.","year":"2022","journal-title":"Anaesthesia"},{"issue":"10","key":"e_1_2_16_75_1","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.3390\/molecules26102940","article-title":"Electrochemical Biosensors in Food Safety: Challenges and Perspectives","volume":"26","author":"Curulli A.","year":"2021","journal-title":"Molecules"},{"issue":"4","key":"e_1_2_16_76_1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3390\/bios9040132","article-title":"Optical Biosensors for Therapeutic Drug Monitoring","volume":"9","author":"Garz\u00f3n V.","year":"2019","journal-title":"Biosensors"},{"issue":"9","key":"e_1_2_16_77_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.3390\/molecules31091440","article-title":"Chloramphenicol Residue Analysis in Food and Environmental Matrices: Regulatory Framework and Advances in Trace\u2010Level Determination","volume":"31","author":"Aresta A. M.","year":"2026","journal-title":"Molecules"},{"issue":"1","key":"e_1_2_16_78_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00604-022-05573-2","article-title":"Photoelectrochemical Biosensor Based on DNA Aptamers and Dual Nano\u2010Semiconductor Heterojunctions for Accurate and Selective Sensing of Chloramphenicol","volume":"190","author":"Yao J.","year":"2023","journal-title":"Microchimica Acta"},{"key":"e_1_2_16_79_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.enzmictec.2025.110745","article-title":"Innovative Nanosensing Methods for Lysozyme Identification","volume":"192","author":"Darvishi M.","year":"2025","journal-title":"Enzyme and Microbial Technology"},{"key":"e_1_2_16_80_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.foodcont.2014.10.003","article-title":"Aptamer\u2010Based Fluorescence Biosensor for Chloramphenicol Determination Using Upconversion Nanoparticles","volume":"50","author":"Wu S.","year":"2015","journal-title":"Food Control"},{"issue":"1","key":"e_1_2_16_81_1","first-page":"1","article-title":"Efflux Pump Knockout Minimizes Crosstalk and Boosts Response in Transcription Factor\u2010Based Biosensors","volume":"19","author":"Lee J.","year":"2025","journal-title":"Journal of Biological Engineering"},{"key":"e_1_2_16_82_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133686","article-title":"Win\u2010Win Cooperation: Magnetic Relaxation Switching Biosensor for Chloramphenicol Detection Based on the Pipet Platform and Antigen\u2010Driven Enzyme\u2010free Dual Signal Amplification Strategy","volume":"385","author":"Hong F.","year":"2023","journal-title":"Sensors and Actuators B: Chemical"},{"key":"e_1_2_16_83_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111845","article-title":"Selective Quantification of Estrogens in Serum With Aptamer\u2010Affinity and LC\u2013MS\/MS Analysis","volume":"207","author":"Yi X.","year":"2024","journal-title":"Microchemical Journal"},{"issue":"3","key":"e_1_2_16_84_1","article-title":"Comparison of Direct and Standardised Antimicrobial Disk Susceptibility Testing for Enterobacterales Isolated From Urine","volume":"78","author":"Barlow S.","year":"2024","journal-title":"New Zealand Journal of Medical Laboratory Science"},{"key":"e_1_2_16_85_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.110124","article-title":"A Reagent\u2010Based Label Free Electrochemiluminescence Biosensor for Ultrasensitive Quantification of Low\u2010Abundant Chloramphenicol","volume":"198","author":"Zhang Y.","year":"2024","journal-title":"Microchemical Journal"},{"key":"e_1_2_16_86_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.112883","article-title":"Ultrabright Fluorescence Probe Mediated Biosensor for Rapid and Ultrasensitive Quantification of Chloramphenicol in Milk","volume":"209","author":"Tao J.","year":"2025","journal-title":"Microchemical Journal"},{"issue":"8","key":"e_1_2_16_87_1","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00216-025-05733-2","article-title":"Aptamer\u2010Based Fluorescence Biosensor for Rapid Detection of Chloramphenicol Based on Pyrene Excimer Switch","volume":"417","author":"Zhang J.","year":"2025","journal-title":"Analytical and Bioanalytical Chemistry"},{"issue":"20","key":"e_1_2_16_88_1","doi-asserted-by":"crossref","first-page":"24172","DOI":"10.1021\/acsanm.4c04933","article-title":"Ultrasensitive Detection of Chloramphenicol in Milk Using a \u201cY\u2010Shaped\u201d SERS Biosensor Based on Magnetic Plasmonic Nanostructures and EXPAR Technology","volume":"7","author":"Zhang R.","year":"2024","journal-title":"ACS Applied Nano Materials"},{"key":"e_1_2_16_89_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.127807","article-title":"Ultrasensitive Detection of Chloramphenicol Using a Performance\u2010Enhanced Fe\/Zn\u2010MIL\u201088B Driven Dual\u2010Mode Biosensing Platform","volume":"291","author":"Liu S.","year":"2025","journal-title":"Talanta"},{"issue":"2","key":"e_1_2_16_90_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00604-024-06872-6","article-title":"A SERS and Colorimetric Dual\u2010Mode Biosensor Based on Stimulus\u2010Responsive DNA\/MOF\u2010Bound Bimetallic Nanozyme for the Ultrasensitive Detection of Chloramphenicol in Food","volume":"192","author":"Zhang R.","year":"2025","journal-title":"Microchimica Acta"},{"key":"e_1_2_16_91_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2024.106114","article-title":"Highly Sensitive and Selective Electrochemical Sensor for the Determination of Chloramphenicol","volume":"129","author":"Chen C.","year":"2024","journal-title":"Journal of Food Composition and Analysis"},{"key":"e_1_2_16_92_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139003","article-title":"Enhancing Electrochemiluminescence for Chloramphenicol Detection Based on the Synergistic Effect of Doped Ti3C2 With Ultrasound","volume":"448","author":"Zhang H.","year":"2024","journal-title":"Food Chemistry"},{"key":"e_1_2_16_93_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139806","article-title":"Well\u2010Ordered Au@Ag NBPs\/SiO2 Nanoarray for Sensitive Detection of Chloramphenicol via DNAzyme\u2010Assisted SERS Sensing","volume":"454","author":"Yang J.","year":"2024","journal-title":"Food Chemistry"},{"key":"e_1_2_16_94_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140184","article-title":"Highly Sensitive Antibiotic Sensing Based on Optical Weak Value Amplification: A Case Study of Chloramphenicol","volume":"458","author":"Meng L.","year":"2024","journal-title":"Food Chemistry"},{"key":"e_1_2_16_95_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117694","article-title":"Wireless & Portable Smartphone Assisted Electrochemical Platform for On\u2010Site Monitoring of Chloramphenicol Drug","volume":"287","author":"Dogra P.","year":"2025","journal-title":"Biosensors and Bioelectronics"},{"key":"e_1_2_16_96_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126430","article-title":"An Aptasensor for Chloramphenicol Determination Based on Dual Signal Output of Photoelectrochemistry and Colorimetry","volume":"277","author":"Wu X.","year":"2024","journal-title":"Talanta"},{"issue":"51","key":"e_1_2_16_97_1","doi-asserted-by":"crossref","first-page":"20312","DOI":"10.1021\/acs.analchem.4c05242","article-title":"Triple Helix Molecular Switch Cascade Multiple Signal Amplification Strategies for Ultrasensitive Chloramphenicol Detection","volume":"96","author":"Deng S.","year":"2024","journal-title":"Analytical Chemistry"},{"key":"e_1_2_16_98_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111990","article-title":"A Dual\u2010Mode Colorimetric and Surface\u2010Enhanced Raman Strategy for Chloramphenicol Detection Based on the Au@Pt Nanozyme and EXPAR","volume":"207","author":"Zhang R.","year":"2024","journal-title":"Microchemical Journal"},{"key":"e_1_2_16_99_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2023.109840","article-title":"Quantitative Detection of Chloramphenicol Residue in Fish Based on SERS Aptasensor Coupled With Magnetic Separation","volume":"197","author":"Yang Z.","year":"2024","journal-title":"Microchemical Journal"},{"key":"e_1_2_16_100_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342283","article-title":"Preparation and Recognition Mechanism Study of an scFv Targeting Chloramphenicol for a Hybridization Chain Reaction\u2010CRISPR\/Cas12a Amplified Fluoroimmunoassay","volume":"1293","author":"Zhang F.","year":"2024","journal-title":"Analytica Chimica Acta"},{"key":"e_1_2_16_101_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137933","article-title":"Molecularly Imprinted Polymers\u2010Aptamer Electrochemical Sensor Based on Dual Recognition Strategy for High Sensitivity Detection of Chloramphenicol","volume":"437","author":"Geng L.","year":"2024","journal-title":"Food Chemistry"},{"key":"e_1_2_16_102_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134962","article-title":"DNAzyme Amplifaction Strategy Coupled With Peanut\u2010Shaped FexOy@MMC@Au and COF@Au Synergistic SERS Enhancement for Ultrasensitive Analysis of Chloramphenicol","volume":"401","author":"Zhang R.","year":"2024","journal-title":"Sensors and Actuators B: Chemical"},{"issue":"4","key":"e_1_2_16_103_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3390\/mi9040142","article-title":"Matrix Effect Study and Immunoassay Detection Using Electrolyte\u2010Gated Graphene Biosensor","volume":"9","author":"Sun J.","year":"2018","journal-title":"Micromachines"},{"key":"e_1_2_16_104_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-026-06312-9","article-title":"Tackling Matrix Effects in Biosensor\u2010Based Analysis of Untreated Blood Plasma","author":"Finocchiaro G.","year":"2026","journal-title":"Analytical and Bioanalytical Chemistry"},{"issue":"11","key":"e_1_2_16_105_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3390\/chemosensors9110299","article-title":"The Challenges of Developing Biosensors for Clinical Assessment: A Review","volume":"9","author":"Prabowo B. A.","year":"2021","journal-title":"Chemosensors"},{"issue":"11","key":"e_1_2_16_106_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00604-023-06017-1","article-title":"A Paper Biosensor for Overcoming Matrix Effects Interfering With the Detection of Sputum Pyocyanin With Competitive Immunoassays","volume":"190","author":"Adrover\u2010Jaume C.","year":"2023","journal-title":"Microchimica Acta"},{"issue":"2","key":"e_1_2_16_107_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s12668-025-01876-9","article-title":"Nanosensors Based on Breathomics for Human Disease Diagnosis: A New Frontier in Personalized Healthcare","volume":"15","author":"Taha B. A.","year":"2025","journal-title":"BioNanoScience"},{"issue":"20","key":"e_1_2_16_108_1","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1007\/s10853-024-09680-8","article-title":"The Recent Progress on Nanomaterial\u2010Based Chemosensors for Diagnosis of Human Exhaled Breath: A Review","volume":"59","author":"Ghawanmeh A. A.","year":"2024","journal-title":"Journal of Materials Science"},{"issue":"4","key":"e_1_2_16_109_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s11051-026-06618-w","article-title":"Polyaniline\/WO3\/Graphene Nanocomposite\u2013Based Chemi\u2010Resistive Sensor for Malaria Detection From Exhaled Breath","volume":"28","author":"Suma M. S.","year":"2026","journal-title":"Journal of Nanoparticle Research"},{"key":"e_1_2_16_110_1","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.ijhydene.2023.08.151","article-title":"High\u2010Performance H2 Sensor Based on Polyaniline\u2010WO3 Nanocomposite for Portable Batteries and Breathomics\u2010Diagnosis of Irritable Bowel Syndrome","volume":"52","author":"Chaudhary V.","year":"2024","journal-title":"International Journal of Hydrogen Energy"},{"key":"e_1_2_16_111_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-981-96-6091-9_10","volume-title":"Nanosensors in Biomedical Technology","author":"Raj R.","year":"2025"}],"container-title":["Analytical Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ansa.70093","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ansa.70093","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ansa.70093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:39:09Z","timestamp":1783539549000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/ansa.70093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":110,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1002\/ansa.70093"],"URL":"https:\/\/doi.org\/10.1002\/ansa.70093","archive":["Portico"],"relation":{},"ISSN":["2628-5452","2628-5452"],"issn-type":[{"value":"2628-5452","type":"print"},{"value":"2628-5452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"2026-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70093"}}