{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:49:03Z","timestamp":1791571743676,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/21827\u20101"],"award-info":[{"award-number":["2017\/21827\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2026\/12458\u20101"],"award-info":[{"award-number":["2026\/12458\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/16091\u20104"],"award-info":[{"award-number":["2022\/16091\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["22\/RP\u20102TF\/1029"],"award-info":[{"award-number":["22\/RP\u20102TF\/1029"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Science Advances"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Proteinuria, defined by an abnormally elevated concentration of proteins in the urine, serves as a critical biomarker for the early detection and diagnosis of preeclampsia. Elevated proteinuria levels adversely affect both maternal and foetal health, increasing the risk of preterm birth and low birth weight. This study focused on the identification of proteinuria in blood samples through Fourier\u2010transform infrared (FTIR) spectroscopy as a diagnostic tool for real\u2010time diagnosis. Blood plasma collected during birth was evaluated in four study groups: pregnant controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a012), pregnant women with proteinuria (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a013), newborn controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a012), newborns with proteinuria (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a014). First, attenuated total reflectance\u2010FTIR spectra of plasma samples were collected for subsequent spectral smoothing, vector normalisation and machine\u2010learning classification with various supervised machine learning algorithms, including several types of Support Vector Machine, K\u2010Nearest Neighbours and decision trees. We obtained (76.1\u00a0\u00b1\u00a03.1)% accuracy, (72.1\u00a0\u00b1\u00a04.8)% sensitivity and (80.4\u00a0\u00b1\u00a03.8)% specificity for pregnant classification, and (90.6\u00a0\u00b1\u00a01.5)% accuracy, (83.3\u00a0\u00b1\u00a02.4)% sensitivity and (98.9\u00a0\u00b1\u00a01.6)% specificity for newborn classification. The vibrational modes corresponding to the predominant biochemical components in blood plasma of pregnant women and newborns were listed. Sensitivity and specificity results demonstrated that FTIR can be a promising tool for early diagnosis and monitoring of individual proteinuria. Although the proposed spectroscopic approach demonstrated promising diagnostic performance, the findings should be interpreted in light of clinical conditions that could affect the biochemical profile. Further studies involving larger and more heterogeneous populations are required to validate the proposed methodology.\n                  <\/jats:p>","DOI":"10.1002\/ansa.70110","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:51:36Z","timestamp":1791568296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting the Risk of Proteinuria Based on Blood Plasma Fourier\u2010Transform Infrared Spectroscopy and Machine Learning Algorithms From Pregnant Women and Newborns"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2320-6525","authenticated-orcid":false,"given":"Camila Lopes","family":"Ferreira","sequence":"first","affiliation":[{"name":"Health Science Post\u2010Graduate Program University of Taubat\u00e9 \u2013 UNITAU  Taubat\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-7688","authenticated-orcid":false,"given":"Sara Maria Santos Dias da","family":"Silva","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Program University of Taubat\u00e9 \u2013 UNITAU  Taubat\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9375-0631","authenticated-orcid":false,"given":"Luma Martins Aleixo de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Dentistry, University of Taubat\u00e9 \u2013 UNITAU  Taubat\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-3552","authenticated-orcid":false,"given":"Vit\u00f3rya Carvalho P\u00e1dua","family":"de Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Program University of Taubat\u00e9 \u2013 UNITAU  Taubat\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Lima","family":"Silva","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Program University of Taubat\u00e9 \u2013 UNITAU  Taubat\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-6935","authenticated-orcid":false,"given":"Sheila Cavalca","family":"Cortelli","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Program University of Taubat\u00e9 \u2013 UNITAU  Taubat\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7754-1855","authenticated-orcid":false,"given":"Rodrigo Augusto","family":"Silva","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Program University of Taubat\u00e9 \u2013 UNITAU  Taubat\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-6152","authenticated-orcid":false,"given":"Jaqueline Maria Brand\u00e3o","family":"Rizzato","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Program University of Taubat\u00e9 \u2013 UNITAU  Taubat\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-9620","authenticated-orcid":false,"given":"Marcelo Saito","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Electronic and Computer Engineering University of Limerick  Limerick Ireland"},{"name":"Health Research Institute (HRI) University of Limerick  Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1063-4624","authenticated-orcid":false,"given":"Lu\u00eds Felipe","family":"Das Chagas e Silva de Carvalho","sequence":"additional","affiliation":[{"name":"Health Science Post\u2010Graduate Program University of Taubat\u00e9 \u2013 UNITAU  Taubat\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010044"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.08.108"},{"key":"e_1_2_12_4_1","unstructured":"National Institute for Health and Care Excellence (NICE)\u201cHypertension in Pregnancy: Diagnosis and Management. 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