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These results are in agreement with other reports of rapid tolerance to sedative effects. However, in contrast to the usual finding of tolerance to anxiolytic actions after 2\u20133 weeks of treatment, in this study no tolerance developed after 23 days of treatment to diazepam's anxiolytic effects in the plus\u2010maze. On withdrawal front the 23 days of diazepam treatment, there was no anxiogenic response in the plus\u2010maze. Therefore, it seems that when chronic administration of diazepam is accompanied by chronic stress, tolerance does not occur to the anxiolytic effects, although it does develop to the sedative effects. Anxiety 1:8\u201312 (1994). \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/anxi.3070010104","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T11:56:13Z","timestamp":1383825373000},"page":"8-12","source":"Crossref","is-referenced-by-count":14,"title":["Noise stress and the development of benzodiazepine dependence in the rat"],"prefix":"10.1002","volume":"1","author":[{"given":"Sandra E.","family":"File","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02247359"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(88)90219-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.470050109"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246946"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430110302"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(85)90037-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.470040111"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(05)80214-3"},{"key":"e_1_2_1_10_1","first-page":"95","volume-title":"Benzodiazepine Dependence","author":"File SE","year":"1993"},{"key":"e_1_2_1_11_1","volume-title":"The Biochemistry of Drug Addiction","author":"File SE","year":"1993"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244232"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(87)90079-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244555"},{"key":"e_1_2_1_15_1","first-page":"336","article-title":"Tolerance to the anxiolytic action of diazepam in rats","volume":"88","author":"Fritz S","year":"1986","journal-title":"Br J Pharmacol"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb14644.x"},{"key":"e_1_2_1_17_1","first-page":"17","volume-title":"Benzodiazepines Divided: A Multidisciplinary Review","author":"Lader M","year":"1983"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(84)90054-1"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(93)90190-5"},{"key":"e_1_2_1_20_1","first-page":"764P","article-title":"Tolerance and withdrawal studies with diazepam and GR38032F in the rat","volume":"96","author":"Oakley NR","year":"1988","journal-title":"Br J Pharmacol"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(85)90031-7"},{"key":"e_1_2_1_22_1","first-page":"452","article-title":"Tolerance and withdrawal to the anti\u2010conflict properties of diazepam following chronic administration in rats","volume":"13","author":"Rock RS","year":"1987","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432715"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(88)90105-2"}],"container-title":["Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanxi.3070010104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anxi.3070010104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:24:39Z","timestamp":1698107079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anxi.3070010104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/anxi.3070010104"],"URL":"https:\/\/doi.org\/10.1002\/anxi.3070010104","archive":["Portico"],"relation":{},"ISSN":["1070-9797","1522-7154"],"issn-type":[{"value":"1070-9797","type":"print"},{"value":"1522-7154","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}