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This preliminary study explores the relationship between social phobia and two well\u2010established immune parameters, serum interleukin\u20102 (IL\u20102) levels, a potent immune and central nervous system modulator, and soluble interleukin\u20102 receptors (SIL\u20102Rs), a well\u2010known marker of T\u2010cell activation. Fifteen subjects with generalized social phobia and 15 healthy volunteers had serum IL\u20102, and SIL\u20102Rs measured by enzyme\u2010linked immunoassay. Subjects with social phobia and normal volunteers had similar mean serum IL\u20102 and SIL\u20102R levels. The data suggest that, unlike other psychiatric disorders, these immune measures may not be used to differentiate patients with generalized social phobia from normal volunteers. Anxiety 1:50\u201353 (1994). \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/anxi.3070010203","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T12:07:08Z","timestamp":1383826028000},"page":"50-53","source":"Crossref","is-referenced-by-count":29,"title":["Serum interleukin\u20102 and soluble interleukin\u20102 receptor levels in generalized social phobia"],"prefix":"10.1002","volume":"1","author":[{"given":"Mark Hyman","family":"Rapaport","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray B.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90116-H"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1080\/00325481.1972.11713319","article-title":"Screening depressed patients in family practices: A rapid technique","volume":"52","author":"Beck A","year":"1972","journal-title":"Postgraduate Medicine"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1989.69.1.1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810030098018"},{"key":"e_1_2_1_6_1","first-page":"23","article-title":"An examination of syndromal validity and diagnostic subtypes in social phobia and panic disorder","volume":"53","author":"Gelernter C","year":"1992","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(85)90111-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.4.437"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-1591(87)90011-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(89)90032-8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90016-U"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199202000-00011"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199303000-00019"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(79)90041-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90086-A"},{"key":"e_1_2_1_16_1","first-page":"21","article-title":"Novel enzyme immunoas\u2010says for the detection of cytokines interleukin\u20101 and interleukin\u20102 in the circulation of normal subjects: 24 hour profile","volume":"5","author":"Paciotti GF","year":"1992","journal-title":"Progress in Neuroendocrino Immunology"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)91137-1"},{"key":"e_1_2_1_18_1","first-page":"31","volume-title":"Psychoimmunology Updates","author":"Rapaport MH","year":"1990"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810030097017"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anxi.3070010106"},{"key":"e_1_2_1_21_1","first-page":"7","article-title":"Increased serum soluble interleukin\u20102 receptors in schizophrenic monozygotic twins","volume":"243","author":"Rapaport MH","year":"1993","journal-title":"Eur Arch of Psych and Neuro"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-8-619"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810010083011"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","unstructured":"SchleiferSJ KellerSE CaraminoM ThorntonJC SteinMM(1983)Suppression of lymphocyte stimulation following bereavement. 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