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Avoiding scopolamine use in specific populations is crucial to prevent adverse effects and harm to patients. This systematic review describes the anticholinergic effects of scopolamine in perioperative patient populations. After searching the available literature, we reviewed the eligible articles to determine whether they met the inclusion criteria (eg, full text, English language, included a discussion of scopolamine's anticholinergic effects in perioperative patients). Twenty\u2010six articles were included in this review. We used The Johns Hopkins Research Evidence Appraisal Tool to appraise the literature. The results of this literature review reveal that clinicians should avoid administering scopolamine to certain perioperative patient populations (ie, pediatric, older adult).<\/jats:p>","DOI":"10.1002\/aorn.12336","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T08:47:44Z","timestamp":1535618864000},"page":"287-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Scopolamine Use in the Perioperative Patient: A\u00a0Systematic Review"],"prefix":"10.1002","volume":"108","author":[{"given":"Lynn","family":"Kassel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn","family":"Shine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura R.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cale","family":"Kassel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"127","article-title":"The effect of transdermal scopolamine on the incidence and severity of postoperative nausea and vomiting in a group of high\u2010risk patients given prophylactic intravenous ondansetron","volume":"74","author":"Jones S","year":"2006","journal-title":"AANA J"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2015.12.009"},{"issue":"10","key":"e_1_2_9_4_1","first-page":"511","article-title":"Reducing the incidence of postoperative nausea and vomiting","volume":"53","author":"Broomhead CJ","year":"1995","journal-title":"Br J Hosp Med"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/62.12.1247"},{"key":"e_1_2_9_6_1","unstructured":"The Medicare Access & CHIP Reauthorization Act of 2015: Path to Value. 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