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High\u2010level disinfection deactivates all types of microorganisms except bacterial spores and prions. If high\u2010level disinfection is not performed correctly, however, contaminated medical or surgical devices could transmit pathogens to patients. Reusable semicritical items may be processed using manual methods when manual chemical high\u2010level disinfection is the only processing method recommended by the manufacturer. The <jats:styled-content style=\"fixed-case\">AORN<\/jats:styled-content> \u201cGuideline for manual chemical high\u2010level disinfection\u201d provides guidance to health care personnel for performing effective manual chemical high\u2010level disinfection and preventing injury associated with the use of high\u2010level disinfectant chemicals. This article focuses on key points of the guideline that address preparation of items for high\u2010level disinfection, use of high\u2010level disinfectants, health care personnel safety, and documentation. Perioperative <jats:styled-content style=\"fixed-case\">RN<\/jats:styled-content>s should review the complete guideline for additional information and for guidance when writing and updating policies and procedures.<\/jats:p>","DOI":"10.1002\/aorn.12373","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T22:48:38Z","timestamp":1538174918000},"page":"399-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Guideline Implementation: Manual Chemical High\u2010Level Disinfection"],"prefix":"10.1002","volume":"108","author":[{"given":"Terri","family":"Link","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"517","volume-title":"Disinfection, Sterilization, and Preservation","author":"Spaulding EH","year":"1968"},{"key":"e_1_2_14_3_1","volume-title":"Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008","author":"Rutala WA","year":"2008"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.10.038"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.12.029"},{"key":"e_1_2_14_6_1","volume-title":"APIC Text of Infection Control and Epidemiology","author":"Rutala WA","year":"2016"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2011.05.002"},{"key":"e_1_2_14_8_1","first-page":"883","volume-title":"Guidelines for Perioperative Practice","year":"2018"},{"key":"e_1_2_14_9_1","first-page":"799","volume-title":"Guidelines for Perioperative Practice","year":"2018"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0b013e3181e9431a"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1359234"},{"key":"e_1_2_14_12_1","volume-title":"Guideline for Use of High\u2010Level Disinfectants & Sterilants in the Gastroenterology Setting","year":"2017"},{"key":"e_1_2_14_13_1","unstructured":"Best practices for the safe use of glutaraldehyde in health care. 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