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During <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>, the surgeon resects cancerous tumors from the peritoneal cavity. During <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content>, a chemotherapy agent is introduced into a solution that flows in and out of catheters in the abdominal cavity for approximately 90 minutes. The chemoperfusate is heated to 42\u00b0 C (107.6\u00b0 F), which kills cancer cells but is nonthreatening to normal cells. A primary goal of combining <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> is to apply targeted regional chemotherapy directly to the peritoneum to destroy residual micrometastatic disease while the tumor burden is minimal and before cancer cells become entrapped by the body's wound\u2010healing processes. Although <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> usually is not curative, it can extend a patient's life expectancy three to five years. This is the first article in a two\u2010part discussion of <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/aorn.12842","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T09:39:05Z","timestamp":1572341945000},"page":"479-499","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy, Part I: Introduction and Indications"],"prefix":"10.1002","volume":"110","author":[{"given":"Debra","family":"Dunn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"issue":"77","key":"e_1_2_13_8_3_2_1_2_2","first-page":"1","article-title":"A critical analysis of the cytoreductive surgery with 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