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Processing encompasses point\u2010of use removal of organic and inorganic material, transport to the processing area, use of chemicals and equipment to clean and decontaminate the item, and inspection for cleanliness and function. Failure to correctly clean and decontaminate surgical instruments can impede subsequent sterilization processes and place patients at risk for developing surgical site infections. The AORN \u201cGuideline for care and cleaning of surgical instruments\u201d provides general guidance for care of reusable medical devices. When processing instruments, perioperative team members should use the guideline in conjunction with the instrument manufacturer\u2019s validated instructions for use. This article discusses the guideline recommendations related to prepurchase evaluation, point\u2010of\u2010use treatment, transport, cleaning and decontamination, and education; it also includes a scenario to illustrate these topics.<\/jats:p>","DOI":"10.1002\/aorn.13495","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T16:00:36Z","timestamp":1629993636000},"page":"241-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Guidelines in Practice: Instrument Cleaning"],"prefix":"10.1002","volume":"114","author":[{"given":"Terri","family":"Link","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"e_1_2_27_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/657912"},{"key":"e_1_2_27_3_1","volume-title":"Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008","author":"Rutala WA"},{"key":"e_1_2_27_4_1","volume-title":"APIC Text of Infection Control and Epidemiology","author":"Jinadatha C","year":"2018"},{"key":"e_1_2_27_5_1","volume-title":"ANSI\/AAMI ST79:2017. 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