{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:25:20Z","timestamp":1790526320067,"version":"4.1.0"},"reference-count":94,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science Foundation Graduate Research Fellowship","award":["DGE-1610403"],"award-info":[{"award-number":["DGE-1610403"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Polymer Sci"],"published-print":{"date-parts":[[2018,6,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In recent decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. As such, the desire to engineer dynamic and functional materials is becoming more prevalent in an effort to achieve precise control over our environment. The combination of controlled radical polymerization and high yielding chemistry strategies provide an excellent basis for the development of the next generation of drug delivery systems. The versatility of polymer chemistries available enables the synthesis of increasingly complex architectures with enhanced delivery specificity and control over the desired properties to interface with biological systems. This tutorial review highlights recent developments in polymer\u2010based approaches to internally responsive nanoparticles for oncology. Presented are concise overviews of the current challenges and opportunities in cancer nanomedicine, common polymer\u2010based architectures, and the basis for internally triggered stimuli\u2013response relationships commonly employed in oncology applications. Examples of the chemistry used in the design of environmentally labile nanomaterials are discussed, and we outline recent advances in creating advanced bioresponsive drug delivery architectures. \u00a9 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci.\n                    <jats:bold>2018<\/jats:bold>\n                    ,\n                    <jats:italic>135<\/jats:italic>\n                    , 46154.\n                  <\/jats:p>","DOI":"10.1002\/app.46154","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T10:38:11Z","timestamp":1517395091000},"source":"Crossref","is-referenced-by-count":68,"title":["Advanced architectures in the design of responsive polymers for cancer nanomedicine"],"prefix":"10.1002","volume":"135","author":[{"given":"Angela M.","family":"Wagner","sequence":"first","affiliation":[{"name":"McKetta Department of Chemical Engineering The University of Texas at Austin Austin Texas 78712"},{"name":"Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin Austin Texas 78712"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Spencer","sequence":"additional","affiliation":[{"name":"McKetta Department of Chemical Engineering The University of Texas at Austin Austin Texas 78712"},{"name":"Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin Austin Texas 78712"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3522-9513","authenticated-orcid":false,"given":"Nicholas A.","family":"Peppas","sequence":"additional","affiliation":[{"name":"McKetta Department of Chemical Engineering The University of Texas at Austin Austin Texas 78712"},{"name":"Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin Austin Texas 78712"},{"name":"Department of Biomedical Engineering The University of Texas at Austin Austin Texas 78712"},{"name":"Division of Pharmaceutics, College of Pharmacy The University of Texas at Austin Austin Texas 78712"},{"name":"Department of Pediatrics, Dell Medical School The University of Texas at Austin Austin Texas 78712"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Biomaterials Science: An Introduction to Materials in Medicine","author":"Ratner B. 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