{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T01:08:06Z","timestamp":1775696886953,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21AA029770"],"award-info":[{"award-number":["R21AA029770"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Polymer Sci"],"published-print":{"date-parts":[[2024,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sterilization of devices is important in hospitals, operating theaters, and emergency rooms. Microdialysis allows in vivo sampling of small molecules and is used for clinical studies. Microdialysis probes are made of soft, flexible, and porous polymeric membranes. They have been traditionally disinfected using either ethanol (which fails to eliminate all microbes and does not satisfy regulatory requirements) or ethylene oxide gas and gamma irradiation (that are expensive and resource\u2010intensive). In this work, three methods for microdialysis probe\u2010sterilization were studied\u2014autoclave and two chemicals (commercially available sterilization solutions): Sporox II and MetriCide. Following sterilization, the regenerated cellulose membranes were characterized under scanning electron microscopy and by measuring the changes in pore characteristics using nitrogen sorption. To determine the effect of sterilization on analyte diffusion through the membrane, microdialysis probes were fabricated, sterilized, and tested with two analytes; ethanol and dopamine. The autoclaved membranes suffered thermomechanical damage and were deemed unfit for further testing. Probes sterilized with the chemical solutions were subsequently characterized by in vitro microdialysis experiments performed under regulated mass flux conditions. It is concluded that autoclaving is not a suitable sterilization technique for the cellulose membranes, while both of the chemical sterilizers were found to be good candidates for sterilization.<\/jats:p>","DOI":"10.1002\/app.55395","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T11:39:31Z","timestamp":1709725171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Experimental investigation of regenerated cellulose microdialysis probe sterilization"],"prefix":"10.1002","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3001-9007","authenticated-orcid":false,"given":"Swayamdipta","family":"Bhaduri","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-399X","authenticated-orcid":false,"given":"Tse\u2010Ang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9870-6333","authenticated-orcid":false,"given":"Jessie","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9809-6423","authenticated-orcid":false,"given":"Maarig","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-8072","authenticated-orcid":false,"given":"Rueben A.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Toxicology, College of Pharmacy The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8106-1830","authenticated-orcid":false,"given":"Tanya","family":"Hutter","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0690099"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb05396.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj070369"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1709-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21734"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.3c00082"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032717308058694"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-11692013000200020"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/0104-1169.0266.2611"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.3.475-479.1993"},{"key":"e_1_2_10_12_1","unstructured":"FDA Official Bulletin https:\/\/www.fda.gov\/regulatory\u2010information\/search\u2010fda\u2010guidance\u2010documents\/submission\u2010and\u2010review\u2010sterility\u2010information\u2010premarket\u2010notification\u2010510k\u2010submissions\u2010devices\u2010labeled(retrieved 31 Aug 2023)."},{"key":"e_1_2_10_13_1","first-page":"254","volume":"1","author":"Takesawa S.","year":"1987","journal-title":"Nephrol. 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