{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:32:01Z","timestamp":1777422721795,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,10,30]],"date-time":"2001-10-30T00:00:00Z","timestamp":1004400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For elucidation of how physiological root resorption of deciduous teeth is initiated, the cellular events that occur surrounding the root of rabbit deciduous teeth before and at the onset of physiological root resorption were observed by means of light and electron microscopy. In addition, the cytodifferentiation of odontoclasts during the initial phase of this root resorption was evaluated by histochemical staining of tartrate\u2010resistant acid phosphatase (TRAP) activity as a marker odontoclasts and their precursors. The present investigation was focused on the physiological root resorption of the deciduous lower second molar of rabbits from Day 0\u20135 postnatally. At birth, the deciduous molar had not erupted yet, and no TRAP\u2010positive cell could be found surrounding the tissue adjacent to the root of the deciduous tooth. TRAP\u2010positive mononuclear cells were initially detected in the coronal portion of the dental follicle of the permanent tooth at Day 1 postnatally. Ultrastructurally, these mononuclear cells had moderate numbers of mitochondria and short\u2010strand rough endoplasmic reticulum, as well as scattered free ribosomes throughout their cytoplasm. TRAP\u2010positive mononuclear cells then appeared in the cementoblast layer immediately adjacent to the surface of the deciduous roots. These mononuclear cells projected cytoplasmic extensions between the cementoblasts and made contact with the cementum. At that time, cell\u2013cell contact was frequently observed between these mononuclear cells and cementoblasts. During 3\u20135 days postnatally, the number of TRAP\u2010positive multinucleate odontoclasts on the root surface gradually increased. They had well\u2010developed ruffled borders and made typical resorption lacunae on the root surface of the deciduous tooth. During this early postnatal period, neither inflammatory cells nor necrotic tissue could be observed surrounding the deciduous root. This study demonstrates that the dental follicle of the permanent tooth as well as the connective tissue adjacent to the deciduous root might play important role in site\u2010 and time\u2010specific recruitment, development, and activation of odontoclasts before and at the onset of physiological root resorption. Anat Rec 264:387\u2013396, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.10017","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:17:12Z","timestamp":1030310232000},"page":"387-396","source":"Crossref","is-referenced-by-count":28,"title":["Cellular events at the onset of physiological root resorption in rabbit deciduous teeth"],"prefix":"10.1002","volume":"264","author":[{"given":"Noriyuki","family":"Sahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,30]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"523","article-title":"Histochemical demonstration of acid phosphatase using AS phosphates","volume":"21","author":"Burstone MS","year":"1958","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091640105"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345710500050201"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(68)90168-4"},{"key":"e_1_2_6_6_1","first-page":"115","article-title":"Factors regulating and modifying dental root resorption","volume":"88","author":"Hammarstr\u00f6m L","year":"1992","journal-title":"Proc Finn Dent Soc"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(73)90072-1"},{"key":"e_1_2_6_8_1","first-page":"103","article-title":"The resorption of the roots of deciduous teeth","volume":"74","author":"Kronfeld R","year":"1932","journal-title":"Dent Cosmos"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(69)90272-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(84)90105-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/35.11.3655324"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.39.23"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345630420021401"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.2000.0205"},{"key":"e_1_2_6_15_1","first-page":"308","article-title":"Advances in bone biology: the osteoclast","volume":"17","author":"Roodman GD","year":"1996","journal-title":"Endocr Rev"},{"key":"e_1_2_6_16_1","first-page":"132","article-title":"Histomorphometric analysis of primary teeth during the process of resorption and shedding","volume":"89","author":"R\u00f6lling I","year":"1981","journal-title":"Scand J Dent Res"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.55.273"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199601)244:1<33::AID-AR4>3.0.CO;2-G"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001830404"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690011101"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(77)90032-2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0252"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345860650080901"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680021001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00893.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001950206"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740090801"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740010301"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.10017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.10017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T11:36:01Z","timestamp":1697024161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.10017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,30]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1002\/ar.10017"],"URL":"https:\/\/doi.org\/10.1002\/ar.10017","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,30]]}}}