{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T11:40:25Z","timestamp":1699789225357},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":15040,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1963,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The anatomy of reproductive organs including histology and cytology of the gonads of one\u2010year\u2010old bovine quintuplets were investigated. The experimental animals were four freemartins and one fertile bull with normal sexual libido. In all four freemartins the cervix was absent but the vestibule and the uterine horns were present. The highest degree of transformation of an ovary toward the male pattern was characterized by absence of germinal epithelium, secondary tunica albuginea, ovarian cortex, and follicles; and by presence of mesothelium, primary tunica, tunica vasculosa, interstitial cells, primary sex cords, centrally located rete, epididymis and ductus deferens.<\/jats:p><jats:p>Least transformation was characterized by partial presence of ovarian cortex with germinal epithelium, secondary tunica and primordial, growing and Graafian follicles with oocytes and nuclei in prophase of heterotypic division and more peripherally located rete. Histological transformation of gonads was parallel to anatomical transformation of reproductive organs. One male embryo was able to masculinize four of the female quintuplets at a lesser degree than that generally reported in the literature for twins and triplets. The histological differences of the right and left gonad of the same freemartin may be due to differences in the stage of embryonic development or, the sensitivity of the gonadal tissues at the time threshold amounts of circulating substances of male origin were available. The presence of oocytes in the luteal structures may indicate that the lutein cells of such structures originate from luteinized unruptured follicles rather than from the interstitial cells.<\/jats:p>","DOI":"10.1002\/ar.1091470403","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T09:10:34Z","timestamp":1109409034000},"page":"457-467","source":"Crossref","is-referenced-by-count":8,"title":["Derivatives of cortical cords in adult freemartin gonads of bovine quintuplets"],"prefix":"10.1002","volume":"147","author":[{"given":"E.","family":"Rajakoski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S. E.","family":"Hafez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000310303"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000330206"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000420103"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/1536856"},{"key":"e_1_2_1_6_1","volume-title":"Marshall's Physiology of Reproduction","author":"Brambell F. W. R.","year":"1960"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090660105"},{"key":"e_1_2_1_8_1","volume-title":"Cytological changes in the bovine corpus luteum during early pregnancy","author":"Foley R. C.","year":"1958"},{"key":"e_1_2_1_9_1","first-page":"1909","article-title":"The structure of reproductive organs in the freemartin, with a theory of thesignificance of the abnormality","volume":"30","author":"Hart D. B.","journal-title":"Proc. Roy. Soc. Edinburgh"},{"key":"e_1_2_1_10_1","first-page":"613","article-title":"Beachtungswerte Genitalmissbildungen bei Drillingen des Rindes","volume":"47","author":"Keller K.","year":"1939","journal-title":"Dtsch. tier\u00e4ztl. Wschr."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.43.1113.611"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400230208"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.3.7.464"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.50.1286.183"},{"key":"e_1_2_1_15_1","first-page":"332","article-title":"The etiology of the free\u2010martin","volume":"12","author":"Lillie F. R.","year":"1922","journal-title":"Cornell Vet."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/1536513"},{"key":"e_1_2_1_17_1","unstructured":"Magnusson H.1918Geschlechtslose Zwillings. Eine gewohnliche Form von Hermaphorditismus beim Rinds. Arch. f. Anat. u. Physiol. S.29\u201362."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-10-8-942"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a105538"},{"key":"e_1_2_1_20_1","first-page":"259","article-title":"A case of triplet calves; with some general consideration regarding multiple gestation in normal uniparous animals","volume":"204","author":"Pearl R.","year":"1912","journal-title":"Maine Agr. Expt. Sta. Bul."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1962.tb01807.x"},{"key":"e_1_2_1_22_1","first-page":"148","article-title":"Ueber das Verhalten des Chorions bei verschiedgeschlectlicher Zwillingsgravidit\u00e4t des Rindes und \u00fcber die Morphologie des Genitalien der weiblichen Tiere, welche enier solchen Gravidit\u00e4t entstammen","volume":"10","author":"Tandler J.","year":"1911","journal-title":"Deut. tier\u00e4rztl. Wchnschr."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400330103"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1091470403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1091470403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T11:03:06Z","timestamp":1699786986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1091470403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,12]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1963,12]]}},"alternative-id":["10.1002\/ar.1091470403"],"URL":"https:\/\/doi.org\/10.1002\/ar.1091470403","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1963,12]]}}}