{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:01:30Z","timestamp":1761894090476},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T00:00:00Z","timestamp":1107302400000},"content-version":"vor","delay-in-days":14522,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1965,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A descriptive study of a 5.5 mm, Horizon XIV human embryo with myeloschisis was made. It is the smallest specimen ever recorded with this anomaly which is considered the embryonic forerunner of the common lumbo\u2010sacral meningomyelocele. The lesion extended from the twenty\u2010fifth existing somite caudally for 1 mm and was characterized by an everted neural plate, a loss of cellular polarity, asymmetry with a spread of neural tissue to the left and possibly a defective external limiting membrane of the neural tube. These findings indicate the lesion occurred before closure of the neural tube and are consistent with the observations of Patten ('53). They definitely do not support Gardner's ('60) hypothesis that rupture of a closed neural tube causes these lesions.<\/jats:p>","DOI":"10.1002\/ar.1091520103","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T10:54:10Z","timestamp":1109415250000},"page":"9-16","source":"Crossref","is-referenced-by-count":51,"title":["Caudal myeloschisis (lumbo\u2010sacral spina bifida cystica) in a five millimeter (Horizon XIV) human embryo"],"prefix":"10.1002","volume":"152","author":[{"given":"Ronald J.","family":"Lemire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Ellsworth C.","family":"Alvord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"13","article-title":"The early development of the human brain","volume":"37","author":"Bartelmez G. W.","year":"1962","journal-title":"Carnegie Inst. Wash. Pub. 621, Contrib. to Embryol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(56)91696-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196307000-00014"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401230106"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.27.2.88"},{"key":"e_1_2_1_7_1","first-page":"489","article-title":"Tissue anomalies of probable neural crest origin in a 20 mm human embryo with myeloschisis","volume":"31","author":"Gruenwald P.","year":"1941","journal-title":"Archiv. Path."},{"key":"e_1_2_1_8_1","first-page":"525","article-title":"Studies in pathology of development. II. Some aspects of defective development in the dorsal midline","volume":"8","author":"Ingalls N. W.","year":"1932","journal-title":"Am. J. Path."},{"key":"e_1_2_1_9_1","first-page":"161","article-title":"The development and reduction of the tail and of the caudal end of the spinal cord","volume":"8","author":"Kunitomo K.","year":"1918","journal-title":"Carnegie Inst., Wash. Pub. 271, Contrib. to Embryol."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091220202"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091260404"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000930304"},{"key":"e_1_2_1_13_1","first-page":"831","volume-title":"Histochemistry, Theoretical and Applied","author":"Pearse A. G. E.","year":"1960"},{"key":"e_1_2_1_14_1","first-page":"826","volume-title":"Histochemistry, Theoretical and Applied","author":"Pearse A. G. E.","year":"1960"},{"key":"e_1_2_1_15_1","unstructured":"Sensenig E. C.1949The early development of the human vertebral column. Carnegie Inst. Wash. Pub. 583 Contrib. to Embryol. 33:23\u201341."},{"key":"e_1_2_1_16_1","unstructured":"Sensenig E. C.1951The early development of the meninges of the spinal cord in human embryos. Carnegie Inst. Wash. Pub. 592 Contrib. to Embryol. 34:145\u2013157."},{"key":"e_1_2_1_17_1","first-page":"46","article-title":"Polysaccharides in tissues of human embryos during the second developmental month","volume":"42","author":"Shapovalov U. N.","year":"1962","journal-title":"Arkh. Anat."},{"key":"e_1_2_1_18_1","unstructured":"Streeter G. L.1942Developmental horizons in human embryos; description of age group XI 13 to 20 somites and age group XII 21 to 29 somite. Carnegie Inst. Wash. Pub. 451 Contrib. to Embryol. 30:211\u2013245."},{"key":"e_1_2_1_19_1","unstructured":"Streeter G. L.1945Developmental horizons in human embryos; description of age group XIII embryos of 4 or 5 mm long and age group XIV period of identation of the lens vesicle. Carnegie Inst. Wash. Pub. 557 Contrib. to Embryol. 31:27\u201363."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901090103"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1091520103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1091520103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T12:59:27Z","timestamp":1699793967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1091520103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,5]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1965,5]]}},"alternative-id":["10.1002\/ar.1091520103"],"URL":"https:\/\/doi.org\/10.1002\/ar.1091520103","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,5]]}}}