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The operation has, in 30 to 40 days, at least three different effects on various portions of the biliary system; (1) proliferative changes of interlobular bile ducts including very small ones, the cholangioles, (2) stimulation of activity of mucin secretion in the lining epithelium of large bile ducts and (3) increased alkaline phosphatase activity of bile canaliculi. In the light of known functions of the gall bladder, the proliferative changes of the interlobular bile ducts and the stimulated mucin secretion of the epithelium of large bile ducts are conceived to be developmental compensations for functions of the gall bladder. However, the increased bile canalicular phosphatase activity seems to indicate that such compensatory mechanism of the intrahepatic biliary system is only partially established at the time of observation.<\/jats:p>","DOI":"10.1002\/ar.1091560108","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T10:38:09Z","timestamp":1109414289000},"page":"55-65","source":"Crossref","is-referenced-by-count":3,"title":["Morphological and histochemical changes in the intrahepatic bile drainage system of the mouse following postnatal cholecystectomy"],"prefix":"10.1002","volume":"156","author":[{"given":"Kazuyori","family":"Yamada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000360304"},{"key":"e_1_2_1_3_1","first-page":"291","volume-title":"Liver Function","author":"Bollman J. 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