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Rec."],"published-print":{"date-parts":[[1970,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Regulation by fetal hypothalamus of adrenocorticotrophic and thyrotrophic function of the fetal anterior hypophysis in the rat was studied by: (1) destruction of the fetal hypothalamic area with an electrocoagulator, (2) compression of the fetal brain by injected paraffin into the fetal skull and (3) induction of fetal exencephaly by hypervitaminosis A in the mother.<\/jats:p><jats:p>The body weight of fetuses in which the hypothalamus was damaged was significantly less than that of littermate controls. Volume of the anterior hypophysis was small in fetuses injected with paraffin. The anterior hypophyses were present in all exencephalies, and showed abnormal forms but no reduction in volume. The adrenals were very small in all fetuses in which the hypothalamus was damaged, accompanied by conspicuous shrinkage of cortical cells, while the thyroids were not changed in volume. The height of the follicular cells decreased slightly.<\/jats:p><jats:p>The observations suggest that in the late period of fetal life in rats, the hypophysial\u2010adrenal system is regulated largely by the hypothalamus, but that the hypophysial\u2010thyroid system is not fully under the control of the hypothalamus.<\/jats:p>","DOI":"10.1002\/ar.1091660411","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T09:56:03Z","timestamp":1109411763000},"page":"659-671","source":"Crossref","is-referenced-by-count":19,"title":["Hypothalamic\u2010hypophysial adrenal and thyroid systems: Observations in fetal rats subjected to hypothalamic destruction, brain compression and hypervitaminosis A"],"prefix":"10.1002","volume":"166","author":[{"given":"Tsuneo","family":"Fujita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunobu","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"507","article-title":"Pathologic anatomy of hypophysis and adrenals in anencephaly","volume":"26","author":"Angevine D. 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