{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:09:31Z","timestamp":1760216971288},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T00:00:00Z","timestamp":1106784000000},"content-version":"vor","delay-in-days":11076,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1974,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Factors contributing to the retino\u2010tectal course of the optic nerves in cyclopic and synophthalmic zebrafish embryos were evaluated. The eye abnormalities were produced by immersing blastula stage eggs in 3% ethanol for two hours. Approximately 50% of cyclopic eyes produced one optic nerve that exits from the eye to innervate one optic tectum. The remaining half of the cyclopic embryos formed optic nerves that were unable to exit from the eyes.<\/jats:p><jats:p>In the synophthalmic embryos, two optic nerves were always produced. These nerves either joined within the partially fused retinas, or shortly after exit from the eyes, to form one nerve which entered the brain and innervated only one optic tectum. Crossing over was not seen within the fused eyes or after exit from the eyes.<\/jats:p><jats:p>The resultant single optic nerves in the cyclopic and synophthalmic embryos innervated the side of the brain penetrated by the nerve. They entered in the floor of the forebrain, diencephalon, or midbrain, usually asymmetrically. Axial growth, directional orientation, and contact guidance of matrix configurations appeared an adequate explanation for the establishment of the retino\u2010tectal pathway.<\/jats:p>","DOI":"10.1002\/ar.1091800211","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T08:21:36Z","timestamp":1109406096000},"page":"377-383","source":"Crossref","is-referenced-by-count":11,"title":["Retino\u2010tectal course of optic nerves in cyclopic and synophthalmic zebrafish embryos"],"prefix":"10.1002","volume":"180","author":[{"given":"Ernest","family":"Schmatolla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400700204"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-76-18471"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401200205"},{"key":"e_1_2_1_5_1","unstructured":"Schmatolla E.1970Analysis of the development of the optic nerve and tectum in the teleost fish; under normal and experimental conditions. Ph.D. Thesis New York University New York."},{"key":"e_1_2_1_6_1","first-page":"555","article-title":"Dependence of tectal neuron differentiation on optic innervation in teleost fish","volume":"27","author":"Schmatolla E.","year":"1972","journal-title":"J. Embryol. exp. Morph."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000100110"},{"key":"e_1_2_1_8_1","first-page":"215","article-title":"Zum Problem der Kreuzung der Nervenbahnen","volume":"3","author":"Szent\u00e1gothai J.","year":"1956","journal-title":"Acta Biol. Acad. Sci. Hungarica, VI, Fasc."},{"key":"e_1_2_1_9_1","first-page":"163","article-title":"Nerve patterns: the mechanics of nerve growth","volume":"5","author":"Weiss P.","year":"1941","journal-title":"Growth, Third Growth Symp."},{"key":"e_1_2_1_10_1","first-page":"346","volume-title":"Analysis of Development","author":"Weiss P.","year":"1955"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1091800211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1091800211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T15:49:50Z","timestamp":1699804190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1091800211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,10]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,10]]}},"alternative-id":["10.1002\/ar.1091800211"],"URL":"https:\/\/doi.org\/10.1002\/ar.1091800211","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,10]]}}}